Symptoms of Secondary Hyperparathyroidism in Patients Receiving Maintenance Hemodialysis: A Prospective Cohort Study

The objective was to determine whether changes in parathyroid hormone (PTH) levels are associated with changes in symptoms within this patient population.Study DesignProspective cohort.Setting &Participants165 adults with hyperparathyroidism secondary to kidney failure diagnosed, a range of dialysis vintages, and receiving regular hemodialysis from a US single-provider organization.ExposureChange in PTH levels over 24 weeks.Outcomes19 putative symptoms of secondary hyperparathyroidism measured up to 4 times using a self-administered questionnaire that assessed severity on a 5-level ordinal scale.Analytical ApproachLongitudinal associations between changes in PTH levels and symptom severity were assessed using generalized additive models.ResultsThe 165 participants studied represented 81% of enrollees (N = 204) who had sufficiently complete data for analysis. Mean age was 56 years and 54% were women. Increases in PTH levels over time were associated (P 
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research

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Source: Pain - Category: Anesthesiology Tags: Topical Review Source Type: research
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Source: Pain - Category: Anesthesiology Tags: Perspectives Source Type: research
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Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
This study used eye-gaze tracking to examine attentional biases to pain-related stimuli in a clinical sample of youth with chronic pain and pain-free controls. The moderating role of attentional control was also examined. Youth with chronic pain (n = 102) and pain-free controls (n = 53) viewed images of children depicting varying levels of pain expressiveness paired with neutral faces while their eye gaze was recorded. Attentional control was assessed using both a questionnaire and a behavioural task. Both groups were more likely to first fixate on high pain faces but showed no such orienting bias for moderate or low pain ...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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