Human Labour is Associated with Altered Regulatory T Cell Function and Maternal Immune Activation.

Human Labour is Associated with Altered Regulatory T Cell Function and Maternal Immune Activation. Clin Exp Immunol. 2019 Oct 16;: Authors: Shah NM, Edey LF, Imami N, Johnson MR Abstract During human pregnancy, Regulatory T cell (Treg) function is enhanced, and immune activation repressed allowing the growth and development of the feto-placental unit. Here, we have investigated whether human labour is associated with a reversal of the pregnancy-induced changes in the maternal immune system. We tested the hypothesis that human labour is associated with a decline in Treg function, specifically their ability to modulate toll-like receptor (TLR)-induced immune responses. We studied the changes in cell number, activation status and functional behaviour of peripheral blood, myometrial (myoMC) and cord blood mononuclear cells (CBMC) with the onset of labour. We found that Treg function declines and that Treg cellular targets change with labour onset. The changes in T-reg function were associated with increased activation of myoMC, assessed by their expression of MHC class II molecules and CBMC inflammatory cells. The innate immune system showed increased activation, as shown by altered monocyte and neutrophil cell phenotypes, possibly to be ready to respond to microbial invasion after birth or to contribute to tissue remodelling. Our results highlight changes in the function of the adaptive and innate immune systems that may have important ...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research