Usefulness of serum opsonic activity measured by chemiluminescence method to assess the invasiveness of colorectal endoscopic mucosal dissection.

Usefulness of serum opsonic activity measured by chemiluminescence method to assess the invasiveness of colorectal endoscopic mucosal dissection. Free Radic Res. 2019 Oct 15;:1-11 Authors: Chinda D, Shimoyama T, Arai T, Sawada K, Akitaya K, Kudo S, Yasuda K, Miyazawa K, Akimoto N, Sato S, Hayamizu S, Tatsuta T, Kikuchi H, Hiraga H, Sawaya M, Sakuraba H, Mikami T, Nakaji S, Fukuda S Abstract Endoscopic submucosal dissection (ESD) is considered as a low-invasive treatment for early-stage colorectal cancer, but the degree of invasiveness has not been well investigated. The aim of this study was to evaluate the physical stress due to colorectal endoscopic submucosal dissection based on changes in serum opsonic activity (SOA). SOA was examined by measuring reactive oxygen species (ROS) produced by neutrophils using lucigenin-dependent chemiluminescence (LgCL) and luminol-dependent chemiluminescence (LmCL). Sixty-nine patients were enrolled into the study and examined SOA in the morning of the day of ESD, the next day, and at 4 days after ESD. The peak height (PH) and area under the curve (AUC) of LgCL showed no significant difference between the day and the next day, whereas the PH and AUC for LgCL were significantly higher 4 days after ESD than on the day of ESD (p < 0.05). In contrast, the PH and AUC of LmCL showed no significant changes during the ESD perioperative period. This difference suggests that SOA changes during the col...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research