The Clinical Features and Risk Factors of Parenchymal Neuro-Behcet's Disease.

The Clinical Features and Risk Factors of Parenchymal Neuro-Behcet's Disease. J Immunol Res. 2019;2019:7371458 Authors: Yan D, Liu J, Zhang Y, Yuan W, Xu Y, Shi J, Li C, Wang Y, Peng L, Yang Y, Zhou J, Wu D, Liu Z, Zeng X, Zhang F, Zheng W, Zhao Y Abstract To investigate the clinical features of parenchymal neuro-Behcet's disease (p-NBD), we retrospectively reviewed the medical records of 1009 BD patients admitted to Peking Union Medical College Hospital from 2000 to 2016. Forty-two patients (25 males and 17 females) with p-NBD and eighty-four age- and sex-matched BD patients without neurological involvement who were served as controls were enrolled. Neurological onset was concomitant with the onset of BD in six cases (14.3%). Pyramidal signs (50.0%) and headache (33.3%) were the most common manifestations. On MRI, the lesions were mainly in the midline structures and hyperintense in the T2-weighted image. The most common lesion was the brainstem (54.8%). Spinal cord involvement was observed in five cases, four of which with cervical cord involvement. Multifocal lesions were observed in 13 patients. Ocular involvement was more prevalent in p-NBD (35.7%) (P = 0.041, OR = 2.36, 95% CI = 1.03-5.44) compared with controls. All patients received corticosteroids and immunosuppressants, mainly cyclophosphamide (39/42). Six patients with severe/refractory condition received biological agents and achieved response measured by decreased Rankin...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research