Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock

In conclusion, the modulation of RNS may be considered an effective adjunct therapy for septic shock, in the case of hypo-responsiveness to norepinephrine.
Source: Shock - Category: Emergency Medicine Tags: Online Articles Source Type: research

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Staphylococcus aureus prosthetic valve endocarditis (SAPVE) has a poor prognosis. There are no large series that accurately describe this entity. This is a retrospective observational study on a prospective cohort from 3 Spanish reference hospitals for cardiac surgery, including 78 definitive episodes of left SAPVE between 1996 and 2016. Fifty percent had a Charlson Index score>5; 53% were health care-related. Twenty percent did not present fever. Complications at diagnosis included: severe heart failure (HF, 29%), septic shock (SS, 17.9%), central nervous system abnormalities (19%), septic metastasis (4%). Hemorrhagi...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Background: Mannose-binding lectin (MBL) is an innate immune protein with strong biologic plausibility for protecting against influenza virus-related sepsis and bacterial coinfection. In an autopsy cohort of 105 influenza-infected young people, carriage of the deleterious MBL gene MBL2_Gly54Asp(“B”) mutation was identified in 5 of 8 individuals that died from influenza-methicillin-resistant Staphylococcus aureus (MRSA) coinfection. We evaluated MBL2 variants known to influence MBL levels with pediatric influenza-related critical illness susceptibility and/or severity including with bacterial coinfections. Metho...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractWe conducted a multicenter study to determine the clinical and microbiological characteristics of health care –associated (HCA) cellulitis in Korea. We retrospectively reviewed the medical records of patients who had been diagnosed with community-onset cellulitis. Of the 2208 cellulitis patients, 232 (10.5%) had HCA cellulitis, 1243 (56.3%) patients were hospitalized, and 15 (0.7%) died in hospital. Compa red with community-acquired (CA) cellulitis, patients with HCA cellulitis were older and more frequently presented with comorbidity and septic shock. A total of 355 microorganisms were isolated from 314 pati...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Antimicrobial resistance (AMR) threats to patient health are becoming more widely recognized and diagnostics manufacturers are making significant progress in combatting the overuse of antibiotics. There is still a lot of work to be done, however. A recent health scare for Rick Bright, Ph.D., director of the Biomedical Advanced Research and Development Authority (BARDA), HHS, the very agency working to combat emerging infectious diseases (EID) and other threats, highlights the lingering risks.  During the 10th Public Meeting of the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
The objective of this retrospective study was to compare the rates of treatment failure, which was a composite of clinical and microbiologic failure, of patients receiving vancomycin and a β-lactam to those receiving vancomycin only for MRSA bacteremia. Patients 16 to 89 years of age with MRSA bacteremia admitted to a university-affiliated hospital from January 1(st), 2014 to December 31(st), 2016 were screened for study inclusion. Patients were eligible if they received>48 hours of vancomycin and a β-lactam (combination group) or vancomycin only (standard group) within 48 hours following bacteremia onset. 182...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Abstract BACKGROUND: Sepsis is one of the main causes of mortality in critically ill patients following progression to septic shock. To investigate the pathophysiologic changes of sepsis, we developed a novel porcine model of septic shock induced by acute respiratory distress syndrome (ARDS) due to methicillin-resistant Staphylococcus aureus(MRSA) pneumonia. METHODS: Twenty-six male Landraces (Lvyuanweiye, Beijing, China) weighing 30 ± 2 kg were divided into four groups: sham group (SH; n = 5); cotton smoke inhalation group (SM; n = 6); MRSA pneumonia group (MR; n = 6); and septic shock group with cott...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
We report a case of an axillary artery aneurysm in a 2 year-old boy with Methicillin Resistant Staphylococcus Aureus (MRSA) septic shock, Acute Respiratory Distress Syndrome (ARDS), and Multi-Organ Dysfunction Syndrome (MODS). Definitive surgical treatment with left axillary artery aneurysm exclusion and bypass with greater saphenous vein graft was performed. To our knowledge, this is the only axillary artery aneurysm ever reported in a child.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Source Type: research
Conclusions In our cohort, increased mortality in recent years in patients with SAB can be explained by baseline condition of patients. MRSA or inappropriate empiric therapy did not explain the increase in mortality. The patients afflicted with SAB changed over time. Epidemiology and outcomes of SAB vary with time and according to geographical location. External validity of studies should be taken into consideration.
Source: Infection - Category: Infectious Diseases Source Type: research
Conclusions In our cohort, increased mortality in recent years in patients with SAB can be explained by baseline condition of patients. MRSA or inappropriate empiric therapy did not explain the increase in mortality. The patients afflicted with SAB changed over time. Epidemiology and outcomes of SAB vary with time and according to geographical location. External validity of studies should be taken into consideration.
Source: Infection - Category: Infectious Diseases Source Type: research
Mortality rates as high as 20 –50% in intensive care unit (ICU) patients owing to severe infections such as sepsis or septic shock are of great concern [1–4]. Staphylococci are common clinical isolates in these patients, and multidrug-resistant (MDR) strains such as meticillin-resistant Staphylococcus aureus (MRSA) and metic illin-resistant coagulase-negative staphylococci (MR-CoNS) are particularly frequent [5–7]. Linezolid was the first commercially available oxazolidinone antibiotic. It exhibits strong in vitro and in vivo activity against these organisms and has become an important drug for treating i...
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research
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