Types of intrapartum hypoxia on the cardiotocograph (CTG): do they have any relationship with the type of brain injury in the MRI scan in term babies?

Types of intrapartum hypoxia on the cardiotocograph (CTG): do they have any relationship with the type of brain injury in the MRI scan in term babies? J Obstet Gynaecol. 2019 Oct 15;:1-6 Authors: Yatham SS, Whelehan V, Archer A, Chandraharan E Abstract Electronic foetal monitoring using cardiotocography is aimed at the timely recognition and management of foetal hypoxia. The primary objective of this study was to examine whether a relationship exists between the types of foetal hypoxia (acute, subacute, evolving, chronic), as identified on cardiotocography and the nature of hypoxic ischaemic encephalopathy, as observed on MRI scans after birth. We conducted a retrospective study of 16 babies born (out of 52,187 births) at St George's Hospital in London during 2006-2017 with a postnatal diagnosis of HIE. Of the 16 babies, only 11 had both MRI scans and CTG traces available. Of those, 9 showed evidence of intrapartum hypoxia on CTG, but only 6 demonstrated evidence of HIE on MRI. Those with acute hypoxia showed abnormalities in the basal ganglia and thalami. A gradually evolving hypoxia or subacute hypoxia was associated with lesions in myelination and cerebral cortex. Impact Statement What is already known on this subject? It has been reported that inter-observer agreement for CTG interpretation is low (30%) when pattern recognition based guidelines are used (Rhöse et al. 2014 ; Reif et al. 2016 ), even amongst 'experts' (Hruban et al. ...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

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Condition:   Cerebral Palsy Interventions:   Diagnostic Test: 3D gait analysis;   Diagnostic Test: MRI scan Sponsors:   Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust;   Keele University;   Imperial College London;   University of Oxford;   University of Aberdeen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsWhen combining the data of 25 included studies, survival in fetal growth restriction pregnancies, diagnosed before 32 weeks of gestation was 81%. Neurodevelopmental impairment was assessed in a minority of surviving children. Individual prognostic counseling on the basis of these results is hampered by differences in patient and pregnancy characteristics within the included patient groups.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Systematic review Source Type: research
Publication date: Available online 15 July 2019Source: NeuroImageAuthor(s): Alex M. Pagnozzi, Jurgen Fripp, Stephen E. RoseAbstractThe deep grey matter (DGM) nuclei of the brain play a crucial role in learning, behaviour, cognition, movement and memory. Although automated segmentation strategies can provide insight into the impact of multiple neurological conditions affecting these structures, such as Multiple Sclerosis (MS), Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease (PD) and Cerebral Palsy (CP), there are a number of technical challenges limiting an accurate automated segmentation of the DGM...
Source: NeuroImage - Category: Neuroscience Source Type: research
CONCLUSION: The instrumented movement analysis is an additional tool that aids clinical practitioners of O/U in the dynamic assessment of pathologic movement and loading patterns. In conjunction with common radiologic imaging it aids in the planning of type and extent of corrective surgical interventions. In the field of orthopaedics and trauma surgery movement analysis can help as an additional diagnostic tool to develop therapeutic strategies and evaluate clinical outcomes. PMID: 31291674 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Conclusions: While here we tested generation-4 hydroxy terminated PAMAM dendrimer, the same dendrimer with different surface modifications and ligands for specific brain targets can potentially exhibit higher brain retention. Our study may serve as a benchmark for quantitative performance of dendrimer-based diagnostics and therapeutics in the CNS diseases.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science I (Neurosciences) Source Type: research
ConclusionsThis case report presents a rare open gastrostomy complication, as well as a differential diagnosis to pneumoperitoneum. Additionally, the medical management poses a successful alternative to an emergency surgical intervention.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
This study was approved by the Animal Experimental Ethics Committee of Southern Medical University, Guangzhou, China (2014-024). All experiments were performed under protocols to meet the requirements of the Association for Assessment and Accreditation of Laboratory Animal Care International and the Experimental Animal Center of Southern Medical University. Male cynomolgus monkeys (Macaca fascicularis) were used, preliminary power analysis being performed to get the proper sample size for three groups (G∗Power 3.1, Heinrich-Heine-Universität Düsseldorf, Germany; alpha = 0.05, power = 0.95; total N = 20 hem...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: In vivo exposure to remifentanil exerts a beneficial effect against excitotoxicity on the developing mouse brain, which is associated with a reduction in the size of ibotenate-induced brain lesion as well as prevention of some behavioral deficits in young mice. The long-term effect of neonatal exposure to remifentanil should be investigated. Introduction The potential neurotoxicity of anesthetics in the perinatal period prompted the US Food and Drug Administration (FDA) to release a drug safety communication warning in 2016 that stated, “repeated or lengthy use of general anesthetics or sedation ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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