Long Non-Coding RNA LINC00152 Regulates Cell Proliferation, Migration And Invasion In Esophageal Squamous Cell Carcinoma Via miR-107/Rab10 Axis

Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

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Conclusions: Alleviated dysphagia might be a useful factor to predict the response to second-cycle NAC for first-cycle SD/PD patients. PMID: 31737296 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Whereas the incidence of esophageal adenocarcinoma is increasing in Western countries, squamous cell carcinoma remains the main histological type of esophageal cancer in Japan (88.3%).1 The nationwide Japanese registry shows that both the frequency of nodal metastasis and efficacy index of lymphadenectomy are highest for the upper mediastinal nodal station in patients with upper (42.9%, 17.6; respectively) and middle (37.4%, 15.0; respectively) esophageal cancer.2 Recurrent laryngeal nerve (RLN) palsy is one of the most feared complications in patients with esophageal cancer who undergo esophagectomy plus meticulous upper ...
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Surgeon at Work Source Type: research
ConclusionsIn this updated nonrandomized study using real world data, we found that the overall survival of LA ‐ESqCC patients treated with dCCRT was not statistically different between those treated with IGRT versus those without IGRT, although the hazard ratio was less than unity, ie, in favor of IGRT. The results should be interpreted with caution given the nonrandomized design and RCTs are needed to cl arify our findings.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Oesophageal cancer (ESCA) is a clinically challenging disease with poor prognosis and health-related quality of life. Here, we investigated the transcriptome of ESCA to identify high risk-related signatures. A total of 159 ESCA patients of The Cancer Genome Atlas (TCGA) were sorted by three phases. In the discovery phase, differentially expressed transcripts were filtered; in the training phase, two adjusted Cox regressions and two machine leaning models were used to construct and estimate signatures; and in the validation phase, prognostic signatures were validated in the testing dataset and the independ...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
In conclusion, these results suggest that p53‐regulated lncRNA uc061hsf.1 is a cancer suppressor gene which is associated wi th tumor progression in ESCC.
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research
Cell Death &Disease, Published online: 18 November 2019; doi:10.1038/s41419-019-2114-zHIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
Authors: Dib J Abstract I read with great interest the paper by Sousa M. Tumor seeding of the fistula tract should be suspected in patients with a previous history of esophageal or nasopharynx squamous cell carcinoma who have undergone a Percutaneous Endoscopic Gastrostomy (PEG) with a persistent gastrocutaneous fistula. Especially after the use of an OTSC. In fact, the "pull technique" for PEG tube placement should not be used in this context. PMID: 31729232 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
In this study, we performed immunohistochemistry (IHC) assay. The results show that RASSF6 is upregulated in ESCC and that the elevated expression level of RASSF6 is associated with lymph node metastasis and poor survival of ESCC patients. Consistent with the clinical observations, the upregulation of RASSF6 greatly promotes ESCC cell proliferation, migration and invasion as well as the cell cycle transition to G1/S phase in vitro. According to models in vivo, the downregulation of RASSF6 considerably inhibits ESCC tumor growth and lung metastasis. Mechanistically, RASSF6 negatively regulates the tumor suppressor tripartit...
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
Circular RNAs (circRNAs), a novel class of noncoding RNAs, have recently drawn much attention in the pathogenesis of human cancers. However, the role of circRNAs in esophageal squamous cell carcinoma (ESCC) re...
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
In conclusion, our study first reported that PTP1B was the positive regulator of EGFR by dephosphorylating MYH9 at Y1408 to promote cell migration and invasion, which revealed the regulatory mechanism of PTP1B-MYH9-EGFR axis in ESCC. PMID: 31735331 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
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