Atypical sarcoid-like granulomatous reactions in lymphoma: natural history and impact on management

Publication date: Available online 16 October 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): R. Ramanan, T. Fancourt, S. Berlangieri, A. Grigg
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

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ConclusionNEAT1 promoted M2 macrophage polarization by sponging miR-214 and then regulating B7-H3, thus accelerating MM progression via the JAK2/STAT3 signaling pathway. Our study revealed novel mechanisms of M2 macrophage polarization and provided new potential clinical therapeutic targets for MM.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
We describe a case of a 76-year-old Caucasian male who presented to the Emergency Department (ED) with weight loss, abdominal pain, and multiple episodes of vomiting and diarrhea. He underwent a laparotomy with an intraluminal mass seen in the cecum. Histology showed atypical intermediate- to large-sized cells involving the full thickness of the bowel wall with numerous mitotic figures and apoptotic bodies. The adjacent uninvolved mucosa demonstrated villous blunting, increased intraepithelial lymphocytes, crypt elongation, and lamina propria plasmacytosis, consistent with the celiac enteropathy. Rare large transformed cel...
Source: Journal of Hematopathology - Category: Pathology Source Type: research
Publication date: Available online 16 October 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Radha Ramanan, Tineke Fancourt, Salvatore Berlangieri, Andrew Grigg
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Sarcoidosis is a clinicopathologic entity consisting of the accumulation of granulomas composed of macrophages and epithelioid cells.1 An association between lymphoma and sarcoidosis or a sarcoid-like reaction has been described, manifesting as 3 scenarios. The first is the development of lymphoma after the development of sarcoidosis, in which a causal relationship between the 2 has been postulated.2 The second is the opposite —the development of sarcoidosis or a sarcoid-like reaction after the diagnosis and treatment of lymphoma.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Publication date: Available online 30 August 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Zuzan Cayci, Kerem Ozturk, Celalettin Ustun, Aazim K. Omer, Erhan Dincer, Zohar Sachs, Bruce A. Peterson, Michael A. LindenAbstractSarcoidosis has been shown to be associated with increased risk of development of several malignancies including lymphomas. On the other hand, “sarcoid-like reactions” in the absence of other clinical signs of sarcoidosis, have also been described in patients who had been treated with chemotherapy for a wide variety of malignancies. In this article, we report 3 cases who had PET...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: Available online 30 August 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Zuzan Cayci, Kerem Ozturk, Celalettin Ustun, Aazim K. Omer, Erhan Dincer, Zohar Sachs, Bruce A. Peterson, Michael A. LindenAbstractSarcoidosis has been shown to be associated with increased risk of development of several malignancies including lymphomas. On the other hand, “sarcoid-like reactions” in the absence of other clinical signs of sarcoidosis, have also been described in patients who had been treated with chemotherapy for a wide variety of malignancies. In this article, we report 3 cases who had PET...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Positron emission tomography (PET) has been a very useful tool for staging, managing, and monitoring the response of patients with lymphoma. However, 18F-fluorodeoxyglucose (FDG)-avid lymphadenopathy needs to be carefully evaluated in these patients, given that FDG/PET scans are highly sensitive, but not specific.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book's index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 1...
Source: Specified Life - Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Conclusions Conclusions: Differentiation between lymphoma and some lymphadenopathy can be difficult on FDG PET/CT, especially with the tuberculous lymphadenitis. A tumor-specific tracer may be a better choice to solve the problem. Key words: FDG PET/CT; lymphoma; misdiagnosis; lymphadenopathy; tuberculous lymphadeniti s
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: MTA I: Leukemia/Lymphoma/Myeloma Posters Source Type: research
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