Association of a novel seven-gene expression signature with the disease prognosis in colon cancer patients.

Association of a novel seven-gene expression signature with the disease prognosis in colon cancer patients. Aging (Albany NY). 2019 Oct 15;11: Authors: Yang H, Liu H, Lin HC, Gan D, Jin W, Cui C, Yan Y, Qian Y, Han C, Wang Z Abstract Older patients who are diagnosed with colon cancer face unique challenges, specifically regarding to cancer treatment. The aim of this study was to identify prognostic signatures to predicting prognosis in colon cancer patients through a detailed transcriptomic analysis. RNA-seq expression profile, miRNA expression profile, and clinical phenotype information of all the samples of TCGA colon adenocarcinoma were downloaded and differentially expressed mRNAs (DEMs), differentially expressed lncRNAs (DELs) and differentially expressed miRNAs (DEMis) were identified. A competing endogenous RNA (ceRNA) network was constructed further and DEMs related with prognosis in the ceRNA network was screened using Cox regression analysis. Risk score models for predicting the prognosis of colon cancer patients were built using these DEMs. A total of 1476 DEMs, 9 DELs, and 243 DEMis between the tumor and normal samples were identified and functional enrichment analyses showed that the DEMs were significantly enriched in the nervous system development, ribosome biogenesis pathways in eukaryotes, and drug metabolism cytochrome P450. Twelve DEMs related with prognosis were screened from the ceRNA network. Thereafter, the ris...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research