Susceptibility of methicillin-resistant Staphylococcus aureus to five quinazolinone antibacterials.

Susceptibility of methicillin-resistant Staphylococcus aureus to five quinazolinone antibacterials. Antimicrob Agents Chemother. 2019 Oct 14;: Authors: Ceballos S, Kim C, Qian Y, Mobashery S, Chang M, Torres C Abstract The in vitro activities of five quinazolinone antibacterials, compounds Q1-Q5, were tested against 210 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC50/MIC90 values (both in μg/ml) were as follows: Q1 (0.5/2), Q2 (1/4), Q3 (2/4), Q4 (0.06/0.25) and Q5 (0.125/0.5). Several strains with high MIC values for some of these compounds (from 8 to >32 μg/ml) exhibited amino-acid changes in the penicillin-binding proteins, which are targeted by these antibacterials. PMID: 31611358 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research