Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion.

We previously showed that n-3-long-chain polyunsaturated fatty acids (n-3 LCPUFA) can enhance apoptosis in breast cancer cells (BC) and that docosahexaenoic acid (DHA; 22:6n-3) can improve the efficacy of chemotherapy drugs commonly used in breast and prostate cancer treatment [1,2]. Suggestions that n-6 LCPUFA, that predominate in Western diets, can elicit pro-cancer effects, as observed in both cell studies and in animal models of cancer [3], instead of the anticancer effects attributed to n-3 LCPUFA, are still controversial.

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - October 15, 2019 Category: Biomedical Science Authors: Iain Brown, Jisun Lee, Alan A. Sneddon, Maria G. Cascio, Roger G. Pertwee, Klaus W.J. Wahle, Dino Rotondo, Steven D. Heys Source Type: research