Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow.

CONCLUSIONS: DPD increased trabecular permeability accompanied with increased nitrite production and MMP-2 levels. PDE inhibitors may increase trabecular outflow by increasing MMP-2 levels and by potentiating NO activity through cyclic GMP in HTMC.
PMID: 31612651 [PubMed - in process]

Source: Korean Journal of Ophthalmology : KJO - October 17, 2019 Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research