NIH Taps URMC to Help Develop New Pain Relievers to Combat Opioid Crisis

University of Rochester Medical Center researchers have been selected as part of a national initiative by the National Institutes of Health to develop new non-addictive treatments for pain to improve patient care and curb the use and abuse of opioids.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news

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Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Victor Fattori, Tiago H. Zaninelli, Fernanda S. Rasquel-Oliveira, Rubia Casagrande, Waldiceu A. VerriAbstractWe now appreciate that the mechanism of resolution depends on an active and time-dependent biosynthetic shift from pro-inflammatory to pro-resolution mediators, the so-called specialized pro-resolving lipid mediators (SPMs). These SPMs are biosynthesized from the omega-3 fatty acids arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), or docosahexaenoic acid (DHA). Despite effective for a fractio...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
In conclusion, morphine administration during adolescence induced persistent changes in negative affect and brain toxicity selectively in male rats, suggesting female rats were resilient to these harmful effects. Given the widespread availability and use of opiate-based painkillers, the interplay between addiction, analgesia and emotional behaviors, and since adolescents and young adult humans are the age group with the highest abuse potential, these results add to the current literature by reporting distinct sex-specific opioid actions when administered in adolescence.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
While recreational marijuana is legal in 11 states as of November 2019, more states gravitating toward legalizing the recreational use of the substance, and 33 states allowing medical marijuana, there’s apparently no stopping this trend. Cannabis, in the form of marijuana, hemp, and cannabidiol (CBD)  is being used for pain relief, to alleviate stress, cope with anxiety, and a number of other mental health disorders and addictions. Yet, there’s a dearth of clinical studies that have been conducted on the overall effects on a user’s health. Clearly, as Crain’s Detroit Business points out, more ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Medications Substance Abuse Cannabis Marijuana Source Type: blogs
What is the Definition of “Opioid”? The definition of opioid is as follows: Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, such as oxycodone, hydrocodone, codeine, morphine, and many others. Opioids work by interacting with the opioid receptors on nerve cells in the body and brain. By interacting with these receptors, opioids medications are able to cut off communication between the pain point on the body to the brain. This chemical interaction gives it’s users pain relief that is too great for ov...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction to Pharmaceuticals fentanyl heroin heroin addiction opiate opiate abuse opiate addiction opiates opioid opioids Source Type: blogs
Conclusions: A series of 10 observational studies was or are being conducted in response to the FDA's postmarketing requirement. All studies have been feasible to conduct, although a validated algorithm for measuring abuse and addiction in databases was not successful. PMID: 31721609 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
The phrase “sacred masculine” can evoke images of patriarchal religiosity.  But it has a different meaning for today’s guest. For Miguel Dean, the sacred masculine is an ideal, embodied by a man who accepts all of his emotions, understands the connectedness of humanity, and is devoted to helping others. Join us as Miguel explains how the sacred masculine is increasingly being recognized as a new model of masculinity to replace the old ideas of what it meant to be a man. This new man embraces all of his humanity and recognizes that part of this is the courage to feel, express and honor the full spect...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Ethics & Morality General Inspiration & Hope Interview LifeHelper Men's Issues Podcast Relationships Self-Help Spirituality The Psych Central Show Source Type: blogs
(University of Texas at Austin, Texas Advanced Computing Center) Today, the Texas Advanced Computing Center (TACC) announced its role as a key collaborator in a first-of-its-kind National Institutes of Health (NIH) grant to investigate and understand the biological characteristics underlying the transition from acute to chronic pain and the subsequent dependence or addiction to opioids.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
Last week I was in Costa Rica, engaging in four nights of ayahuasca ceremonies with a group of friends who invited me to share this experience with them. This was the first time I’ve taken ayahuasca. It’s illegal in the USA and most other countries, but it’s legal in Costa Rica. Taking ayahuasca four nights in a row was physically challenging – nausea, vomiting, dizziness, and more – but I gained many insights from the alternative perspectives it provided. I actually count last week among the most cherished weeks of my life. I’d like to record a video (or a few videos) to share the...
Source: Steve Pavlina's Personal Development Blog - Category: Psychiatry & Psychology Authors: Tags: Creating Reality Source Type: blogs
CONCLUSIONS: This study reveals considerable negativity and concern about current treatment services for prescription and OTC drug dependence in England from the perspective of those working in such services. Policy and practice improvement are suggested to improve outcomes for this neglected group in relation to increasing funding, guidelines and awareness. PMID: 31718716 [PubMed - in process]
Source: Addiction Science and Clinical Practice - Category: Addiction Authors: Tags: Addict Sci Clin Pract Source Type: research
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