Breath selection methods for compact mass spectrometry breath analysis

Compact mass spectrometry (CMS) is a versatile and transportable analytical instrument that has the
potential to be used in clinical settings to quickly and non-invasively detect a wide range of
relevant conditions from breath samples. The purpose of this study is to optimise data preprocessing
protocols by three proposed methods of breath sampling, using the CMS. It also lays out a general
framework for which data processing methods can be evaluated. Methods. This paper considers data
from three previous studies, each using a different breath sampling method. These include a
peppermint washout study using continuous breath sampling with a purified air source, an exercise
study using continuous breath sampling with an ambient air source, and a single breath sampling
study with an ambient air source. For each dataset, different breath selection (data preprocessing)
methods were compared and benchmarked according to predictive performance on a validation set and
quantitativ...

Source: Journal of Breath Research - September 28, 2019 Category: Respiratory Medicine Authors: Kerry Rosenthal, Dorota M Ruszkiewicz, Hayden Allen, Martin R Lindley, Matthew A Turner and Eugenie Hunsicker Source Type: research