A Randomized, Controlled, Multi-center Clinical Investigation to Evaluate and Compare the Safety and Efficacy of Using ZOOM Reperfusion Catheters and Stent Retrievers in Thrombectomy Procedures to Treat Acute Ischemic Stroke Patients

Conditions:   Ischemic Stroke;   Acute Stroke Interventions:   Device: ZOOM Reperfusion Catheter;   Device: Trevo® Pro (Stryker) or Solitaire™ (Medtronic) Stent Retrievers Sponsor:   Imperative Care, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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AbstractPurposeCirculating caspase-3 levels at 24  h of ischemic stroke were found to be associated with poorer functional neurological outcome in a previous study. The aim of this study was to determine whether there is an association between serum caspase-3 levels and early mortality in patients with malignant middle cerebral artery infarction ( MMCAI).MethodsWe included patients with MMCAI defined as computer tomography showing ischemic changes in more than 50% of the middle cerebral artery territory and Glasgow Coma Scale  ≤ 8. Serum caspase-3 levels at days 1, 4, and 8 of MMCAI were determined.Re...
Source: Neurocritical Care - Category: Neurology Source Type: research
Results of Treat Stroke to Target (TST), a rare cholesterol study in patients with a history of ischemic stroke, explore the benefits of treating to a lower LDL target.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
Publication date: Available online 20 November 2019Source: Neurochemistry InternationalAuthor(s): Linlin Yuan, Shibo Sun, Xiaohan Pan, Liqin Zheng, Yuting Li, Jingyu Yang, Chunfu WuAbstractStroke is the leading cause of long-term motor disability and cognitive impairment beside the acute brain injury. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. Our previous study showed that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, isolated from leaves of Panax pseudoginseng subsp, exerted neuroprotective effects on stroke by alleviating autophagy/lysosomal defects and repres...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
AbstractPurpose of reviewPregnancy places women at a higher risk for hemorrhagic and ischemic strokes. This review discusses the pathophysiological mechanisms underlying this increased risk, management considerations for pregnant patients, and ways to decrease the risk of stroke in this patient population.Recent findingsRates of ischemic and hemorrhagic pregnancy-associated stroke have increased over the past 20  years, particularly events associated with hypertensive disorders of pregnancy. There is a growing body of evidence supporting the use of acute reperfusion therapies in ischemic pregnancy-associated stroke in...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Background: Accurate assessment of the frequency of large vessel occlusion (LVO) is important to determine needs for neurointerventionists and thrombectomy-capable stroke facilities. Current estimates vary from 13% to 52%, depending on acute ischemic stroke (AIS) definition and methods for AIS and LVO determination. We sought to estimate LVO prevalence among confirmed and suspected AIS patients at 2 comprehensive US stroke centers using a broad occlusion site definition: internal carotid artery (ICA), first and second segments of the middle cerebral artery (MCA M1,M2), the anterior cerebral artery, vertebral artery, basila...
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
Background and Purpose: Various pathogenesis are presumed to be involved in the etiology of embolic stroke of undetermined source (ESUS), which has a high recurrence rate, and much remains unknown about the clinical subtype of recurrent stroke. The purpose of this study was to clarify the pathogenesis of ESUS using the ASCOD classification for ESUS patients and to examine the factors involved in the recurrence of ischemic stroke. Methods: The subjects of this study were 236 of these patients who fulfilled the criteria for ESUS.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
AbstractPurpose of ReviewTo review randomized interventional clinical and imaging trials that support lower targeted atherogenic lipoprotein cholesterol goals in “extreme” and “very high” atherosclerotic cardiovascular disease (ASCVD) risk settings. Major atherosclerotic cardiovascular event (MACE) prevention among the highest risk patients with ASCVD requires aggressive management of global risks, including lowering of the fundamental atherogenic ap olipoprotein B-associated lipoprotein cholesterol particles [i.e., triglyceride-rich lipoprotein remnant cholesterol, low-density lipoprotein cholester...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Conditions:   Stroke, Ischemic;   Stroke, Acute Intervention:   Drug: Plasminogen Activators Sponsor:   Ho Chi Minh City University of Medicine and Pharmacy Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Funding Opportunity RFA-NS-20-012 from the NIH Guide for Grants and Contracts. This initiative will provide two years of support for planning activities necessary for initiating a Phase III clinical trial designed to validate VCID biomarkers and/or treat patients with VCID. The full spectrum of VCID is in scope, and the one or more VCID disorders(s) to be targeted in the trial must be clearly specified in the application, for example (but not limited to): vascular insults including clinical stroke, silent infarcts and microinfarcts, leukoaraiosis, cerebral amyloid angiopathy (CAA), transient ischemic attack (TIA), micro-b...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
s N Abstract Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitive impairment. Long-term hypertension, complicated or not by the occurrence of ischemic stroke, is often reviewed on its vascular side, and parenchymal consequences are put aside. Here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron conne...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
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