Rate-dependent constitutive modeling of brain tissue.

Rate-dependent constitutive modeling of brain tissue. Biomech Model Mechanobiol. 2019 Oct 14;: Authors: Hosseini-Farid M, Ramzanpour M, McLean J, Ziejewski M, Karami G Abstract In this paper, the dynamic behavior of bovine brain tissue, measured from a set of in vitro experiments, is investigated and represented through a nonlinear viscoelastic constitutive model. The brain samples were tested by employing unconfined compression tests at three different deformation rates of 10, 100, and 1000 mm/s. The tissue exhibited a significant rate-dependent behavior with different compression speeds. Based on the parallel rheological framework approach, a nonlinear viscoelastic model that captures the key aspects of the rate dependency in large-strain behavior was introduced. The proposed model was numerically calibrated to the tissue test data from three different deformation rates. The determined material parameters provided an excellent constitutive representation of tissue response in comparison with the test results. The obtained material parameters were employed in finite element simulations of tissue under compression loadings and successfully verified by the experimental results, thus demonstrating the computational compatibility of the proposed material model. The results of this paper provide groundwork in developing a characterization framework for large-strain and rate-dependent behavior of brain tissue at moderate to high strain ...
Source: Biomechanics and Modeling in Mechanobiology - Category: Biomedical Science Authors: Tags: Biomech Model Mechanobiol Source Type: research