Polymyxin derivatives as broad-spectrum antibiotic agents.

Polymyxin derivatives as broad-spectrum antibiotic agents. Chem Commun (Camb). 2019 Oct 15;: Authors: Su M, Wang M, Hong Y, Nimmagadda A, Shen N, Shi Y, Gao R, Zhang E, Cao C, Cai J Abstract We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model. PMID: 31612170 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research