"Off-on" switching of intracellular singlet oxygen release under biocompatible conditions.

"Off-on" switching of intracellular singlet oxygen release under biocompatible conditions.
Chem Commun (Camb). 2019 Oct 15;:
Authors: Ucar E, Xi D, Seven O, Kaya C, Peng X, Sun W, Akkaya EU
Abstract
Precise spatiotemporal control of singlet oxygen generation is of immense importance considering its involvement in photodynamic therapy. In this work, we present a rational design for an endoperoxide which is highly stable at ambient temperatures yet, can rapidly be converted into a highly labile endoperoxide, thus releasing the "stored" singlet oxygen on demand. The "off-on" chemical switching from the stable to the labile form is accomplished by the reaction with fluoride ions. The potential utility of controlled singlet oxygen release was demonstrated in cell cultures.
PMID: 31613284 [PubMed - as supplied by publisher]

Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Ucar E, Xi D, Seven O, Kaya C, Peng X, Sun W, Akkaya EU Tags: Chem Commun (Camb) Source Type: research