Updating the evidence on drugs to treat overactive bladder: a systematic review
AbstractIntroductionOveractive bladder (OAB) is a common condition, increasing with age and affecting quality of life. While numerous OAB drugs are available, persistence is low. We evaluated evidence published since 2012 to determine if newer drugs provided better efficacy and harm profiles.MethodsWe searched MEDLINE and the Cochrane Library from 2012 to September 2018 using terms for included drugs and requested information from manufacturers of included drugs. We performed dual review of all systematic review processes, evaluated study quality, and conducted meta-analyses using random effects models.ResultsIn addition to 31 older studies, we included 20 trials published since 2012 (N = 16,478; 4 good, 11 fair, and 5 poor quality). Where statistical differences were found, they were clinically small (reductions of
CONCLUSION: MiR-144 regulates proliferation and apoptosis of HG-induced AC16 cardiomyocytes through targeting the CTRP3/JNK signaling pathway, providing a novel avenue for treatment of DCM. PMID: 32211094 [PubMed]
RARITAN, NJ, March 28, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced the VOYAGER PAD study met its primary efficacy and principal safety endpoints, demonstrating the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily) plus aspirin (100 mg once daily) was superior to aspirin alone in reducing the risk of major adverse limb and cardiovascular (CV) events by 15 percent in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization, with similar rates of TIMI major bleeding. VOYAGER PAD is the only study to show a significant benefit...
ConclusionThe Turkish version of the ISC-Q can be considered a reliable and valid tool for the evaluation of quality of life related to catheterization in patients with SCI.
AbstractAvailable evidence suggests a pathogenetic role of sleep breathing disorders in both atrial and ventricular arrhythmias with non-negligible clinical implications. Scientific literature has reported convincing findings on the link between sleep breathing disorders and arrhythmias. The coexistence of these conditions should be appropriately managed because OSA treatment may reduce arrhythmia recurrence. This paper provides an overview of the main physiopathologic mechanisms underlying the association between sleep apnea and arrhythmias and discusses the impact of sleep apnea on arrhythmia management in clinical practice.
Publication date: April 2020Source: Case Reports in Women's Health, Volume 26Author(s): Katelyn E. Tondo-Steele, Nicole M. Book
Condition: Stress Urinary Incontinence Intervention: Device: Nolix Device Sponsor: Gynamics LTD Completed
High risk TMT finding – MCQ Which of the following is not a high risk finding during treadmill test: a) Ischemic changes occurring stage 1 or 2 b) Progressive fall in blood pressure c) Progressive rise in blood pressure d) Arrhythmia induced during arrhythmia Post your answer as a comment below
ConclusionUTI is a significant but common problem in elderly population. Physicians who care for frail elderly patients must be aware of the challenges in the management of asymptomatic UTI, and identifying symptomatic UTI in this population, and their appropriate management strategies. There is strong need in studies to evaluate nonantimicrobial therapies in the prevention of UTI for the frail elderly population.
Photo credit Fuad Obasesan Dear Carol: My mom has moderate dementia and she seems to like the idea of living in a care community. We’ve done all of the preliminary work, but the social worker at the assisted living facility recently told me that they wouldn’t want me to visit Mom for the first two weeks. Their reasoning is that Mom would adjust better if she has no alternative but to depend on them for help. I’m uncomfortable with this idea because I feel that Mom will need my help settling in. I think that I’d feel abandoned if someone just left me like that. Is not letting the family vi...
AbstractThe prevalence of children with neurological impairment (NI) presenting feeding difficulties and gastrointestinal symptoms is rising. The most recent guidelines recommend early nutritional assessment and intervention in order to prevent undernutrition and growth failure, along with the proper diagnosis and treatment of some frequent gastrointestinal symptoms, such as gastroesophageal reflux disease (GERD) and constipation, which can further worsen the feeding process and nutritional status. Nonetheless, the nutritional issues and growth deficits of children with NI are often considered to be of low priority or unde...