Berberis lycium fruit extract attenuates oxi-inflammatory stress and promotes mucosal healing by mitigating NF- κB/c-Jun/MAPKs signalling and augmenting splenic Treg proliferation in a murine model of dextran sulphate sodium-induced ulcerative colitis

ConclusionThese observations provide compelling evidence that BLFE could be considered as a viable natural strategy in the prevention and management of ulcerative colitis.Graphic abstract
Source: European Journal of Nutrition - Category: Nutrition Source Type: research

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 Have you ever wondered what it’s like to be an inpatient in a psych ward? In this two-part series, we go into detail about Gabe’s inpatient stay starting with the events that lead him to be an inpatient, and what his days were like after he was admitted. We talk about common misconceptions that you may have around what happens while you’re admitted, what your day looks like and who you’d spend time with. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder. He is the author of t...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Depression General Not Crazy Podcast Psychiatry Psychotherapy Suicide Treatment Source Type: blogs
CONCLUSIONS: the prevalence of CeD in our patients with IBD was higher than that reported in the literature for other series of patients with IBD. A combination of anti-tTG testing and CeD genetics may screen patients for CeD in this population of patients with IBD. PMID: 31718200 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Publication date: 14 November 2019Source: Cell, Volume 179, Issue 5Author(s): Bing Huang, Zhanghua Chen, Lanlan Geng, Jun Wang, Huiying Liang, Yujie Cao, Huan Chen, Wanming Huang, Meiling Su, Hanqing Wang, Yanhui Xu, Yukun Liu, Bingtai Lu, Huifang Xian, Huiwen Li, Huilin Li, Lu Ren, Jing Xie, Liping Ye, Hongli WangSummaryPediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the growth of infants and children, but the etiopathogenesis underlying disease subtypes remains incompletely understood. Here, we report single-cell clustering, immune phenotyping, and risk gene analysis for chil...
Source: Cell - Category: Cytology Source Type: research
Conditions:   Ulcerative Colitis;   Telemedicine Intervention:   Device: Constant-Care Sponsors:   Nordsjaellands Hospital;   Calpro AS Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aimed to assess the impact of primary sclerosing cholangitis on disease phenotype and its course in patients with ulcerative colitis. DESIGN: This is a retrospective study with 3:1 matched cohorts. SETTINGS: Tertiary care center’s electronic database was used for data analysis from 2000 and 2018. PATIENTS: Of 782 patients with ulcerative colitis, 77 patients who had coincident primary sclerosing cholangitis were included. MAIN OUTCOME MEASURES: The primary outcomes evaluated were disease characteristics including colonic disease activity, temporal change of disease course, colorectal neoplasia,...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Inflammatory Bowel Disease Source Type: research
CONCLUSIONS: The requirement for proctectomy after hemorrhoidectomy/skin tag excision appears to be secondary to the natural disease course of perianal Crohn’s disease rather than perianal intervention. Selective hemorrhoidectomy and skin tag excision in patients with well-controlled luminal disease should be considered. See Video Abstract at http://links.lww.com/DCR/B55. HEMORROIDECTOMÍA ASOCIADA A LA EXCISIÓN DE PLICOMAS EN CASOS DE ENFERMEDAD INFLAMATORIA INTESTINAL: ¿ANUNCIO DE FATALIDAD O SIMPLEMENTE EVOLUCIÓN NATURAL DE LA ENFERMEDAD? ANTECEDENTES: Está controvertida la ...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Inflammatory Bowel Disease Source Type: research
Publication date: Available online 13 November 2019Source: Carbohydrate PolymersAuthor(s): Shao-qing Chen, Yan-qing Song, Cheng Wang, Shan Tao, Fang-ying Yu, Hai-ya Lou, Fu-qiang Hu, Hong YuanAbstractTargeted and sensitive drug release at the colitis site is critical for the effective therapy of ulcerative colitis and reduction of side effects from the drug. Herein, we used 3,3’-dithiodipropionic acid (DTPA) to covalently link quercetin (Qu) and glyceryl caprylate-caprate (Gcc) via ester bonds to prepare Qu-SS-Gcc lipid nanoparticles (Qu-SS-Gcc LNPs). Dexamethasone (Dex) was used as a model drug, and chitosan (CSO) w...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Conclusions: Evidence from clinical trials support that there are no differences in efficacy or safety of continuing the treatment with Infliximab BRP or exchanging into its biosimilar in patients with medical conditions approved in EsSalud. Financial analysis shows that the biosimilar introduction produce savings in purchasing institutional budget. Therefore, based on cost-opportunity principle, exchanging into biosimilar in patients receiving the original Infliximab, is a valid therapeutic alternative in the Peruvian Social Security.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsTogether, the current study demonstrates that resveratrol ‐mediated attenuation of colitis may be regulated by miR‐31 through induction of Tregs and miR‐31 may serve as a therapeutic target for human colitis.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
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