A healthy patient with positive Mantoux test but negative Quantiferon Gold assay and no evidence of risk factors – to treat or not to treat?
Publication date: Available online 15 October 2019Source: IDCasesAuthor(s): Lazara Karelia Montane Jaime, Patrick E. Akpaka, Sehlule Vuma, Angel A Justiz-VaillantAbstractA 56-year-old woman who vaccinated as a child with the Bacillus Calmette-Guerin (BCG), now tests positive to the tuberculin skin test (TST) but test negative to the Quantiferon Gold assay. She has no history of tuberculosis contact and is asymptomatic. This dilemma now is, should be treated for tuberculosis or not, based only on the TST results? To prevent these false positive results with TST and avoid treatment with isoniazid (INH) it may be helpful to use interferon-gamma release assay (IGRA) instead, which unlike the TB skin test is not affected by prior BCG vaccination.
Abstract The guinea pig model of tuberculosis is used extensively to assess the efficacy of novel tuberculosis vaccines. There are established parameters to determine vaccine efficacy in this model, but the science community currently lacks established biomarkers for early detection and monitoring of experimental disease in guinea pigs. To define a set of biomarkers that could be used as benchmarks for disease progression and early endpoint criteria, we assessed serum biochemical and hematology parameters in 2 groups of guinea pigs-one vaccinated with the attenuated Mycobacterium bovis vaccine strain (BCG) and one...
Delivering the only approved tuberculosis vaccine intravenously greatly enhanced its ability to protect rhesus monkeys from infection.
Publication date: Available online 11 January 2020Source: Research in Veterinary ScienceAuthor(s): Mitchell V. Palmer, W. Ray Waters, Tyler C. ThackerAbstractMycobacterium bovis is the cause of tuberculosis in most mammalian species, most notably cattle and other members of the family Bovidae; however, many species of the family Cervidae are also susceptible. In North America, tuberculosis has been identified in both captive and free-ranging cervids. Captive cervids are tested for tuberculosis following many of the same guidelines applied to cattle, including intradermal tuberculin testing using M. bovis purified protein d...
Abstract An estimated one quarter of persons worldwide are infected with Mycobacterium tuberculosis. In 2018, the World Health Organization issued revised guidance on BCG vaccine for high-risk groups. The World Health Organization should consider guiding countries on a case-by-case basis in developing appropriate BCG policies to deliver equitable healthcare and protect public health. PMID: 31922950 [PubMed - as supplied by publisher]
This study represents an important step toward biologically validating the direct PBMC MGIA for use in TB vaccine development and furthermore demonstrates the utility of this assay in determining relevant immune mechanisms and pathways of protection.
Nature, Published online: 07 January 2020; doi:10.1038/d41586-020-00003-wThe BCG vaccine is nearing its centenary. A new delivery method could protect more people from one of the world’s biggest killers.
THURSDAY, Jan. 2, 2020 -- The tuberculosis (TB) vaccine is far from infallible, but new animal research suggests the problem is not the vaccine but how it is delivered. When given to monkeys intravenously rather than as an injection, the vaccine...
A new study from the National Institutes of Health has found that administering the tuberculosis vaccine straight into the vein was more effective than the shot injected into the skin.
Giving the vaccine intravenously to monkeys provided 90% protection against tuberculosis. More testing is needed before humans can be inoculated that way.
Delivering the only vaccine known to treat tuberculosis via veins rather than the skin can dramatically increase its potency, tests in monkeys show