HLA Screening for Dapsone Hypersensitivity in India —A Long Way Ahead

To the Editor We congratulate Liu et al for their work involving proactive HLA screening to prevent dapsone hypersensitivity syndrome (DHS) in patients with leprosy. Herein, we describe the practical difficulties in translating this screening into clinical practice in India.
Source: JAMA Dermatology - Category: Dermatology Source Type: research

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Abstract A common technique used to differentiate bacterial species and to determine evolutionary relationships is sequencing their 16S ribosomal RNA genes. However, this method fails when organisms exhibit high similarity in these sequences. Two such strains that have identical 16S rRNA sequences are Mycobacterium indicus pranii (MIP) and Mycobacterium intracellulare. MIP is of significance as it is used as an adjuvant for protection against tuberculosis and leprosy; in addition, it shows potent anti-cancer activity. On the other hand, M. intracellulare is an opportunistic pathogen and causes severe respiratory i...
Source: Analytical and Bioanalytical Chemistry - Category: Chemistry Authors: Tags: Anal Bioanal Chem Source Type: research
AbstractLeprosy is a chronic infectious disease of the skin and peripheral nerves that presents a strong link with the host genetic background. Different approaches in genetic studies have been applied to leprosy and today leprosy is  among the infectious diseases with the greatest number of genetic risk variants identified. Several leprosy genes have been implicated in host immune response to pathogens and point to specific pathways that are relevant for host defense to infection. In addition, host genetic factors are also inv olved in the heterogeneity of leprosy clinical manifestations and in excessive inflammatory...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
We report a case of resistant bacilli in late reaction and discuss the implications of this finding. PMID: 31707970 [PubMed - as supplied by publisher]
Source: Tropical Doctor - Category: Tropical Medicine Authors: Tags: Trop Doct Source Type: research
In 2013, Lepra Bangladesh (a non-government organization) and the National Leprosy Programme of the Directorate General of Health Services under the Ministry of Health and Family Welfare, Bangladesh implemente...
Source: BMC Health Services Research - Category: General Medicine Authors: Tags: Research article Source Type: research
Authors: Thangaraju P, Venkatesan AS PMID: 31665397 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
by Diana N. J. Lockwood, Saba Lambert, Aparna Srikantam, Joydeepa Darlong, V. V. Pai, C. Ruth Butlin, Barbara de Barros, Edessa Negera, Stephen L. Walker
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Authors: Pradana KA, Widjaya MA, Wahjudi M Abstract In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From ...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
ABSTRACT This paper reviews aspects of the life and work of Professor Louis Ranvier 140 years after the publication of Le çons sur l ’ histologie du syst ème nerveux, published in 1878, and shows the importance of the histological description of myelinated fibers of the nodes of Ranvier.RESUMO Os autores apresentam uma revis ão sobre aspectos da vida e obra do Professor Louis Ranvier 140 anos após a publicação de seu livro Leçons sur l ’ histologie du syst ème nerveux publicado em 1878 e mostra a importância da descrição histológ...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
DiscussionEven in this previously highly VL endemic area, PKDL is a rare condition. Nevertheless, even a single case can trigger a new VL outbreak. Leprosy is also a rare disease, but current prevalence is over 17 times the elimination threshold proclaimed by WHO. Both diseases require continued surveillance. Active case finding for leprosy can be recommended among household members and close neighbors of leprosy patients but would not be feasible for entire populations. Periodic skin camps may be a feasible and affordable alternative.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
In conclusion, this review reported that IL-37 has a crucial role in reducing infection-associated inflammation and has a good impact on inflammation-induced pathology. However, tight regulation that achieved balance between effector immune responses that required for pathogen elimination and limited tissue damage that resulted from excessive inflammation should be existed in the potential IL-37 therapy to prevent clinical complications of a disease. PMID: 31633447 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
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