HLA Screening for Dapsone Hypersensitivity in India —A Long Way Ahead—In Reply

In Reply We thank Dr Bishnoi and colleagues for their interest in our study and for sharing us with the current epidemic status of leprosy and the focus of the disease control activities in India.
Source: JAMA Dermatology - Category: Dermatology Source Type: research

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Conclusion: The Mtb infection status had a significant impact on mycobacterial growth inhibition in PBMC from healthy adults in South Korea, a country with an intermediate burden of tuberculosis, with healthy controls showing the greatest mycobacterial growth inhibition. Introduction Pulmonary tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis (Mtb), which is a significant burden for the world, reaching 9.6 million new TB cases and 1.5 million deaths per year (1). Also, just under a quarter of the global population is latently infected with Mtb, and 5–10% of them will dev...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Jack Niedenthal, the secretary of Health and Human Development in the Republic of Marshall Islands stands in front of the poster that records the dark past of the Pacific island nation and the need for good healthcare. Credit: Stella Paul/IPS By Stella PaulMAJURO, Apr 5 2019 (IPS) In Jack Niedenthal’s office in Majuro, there is an ominous reminder of the dark history of the Marshall Islands—once the site for dozens of nuclear tests conducted by the United States between 1946 and 1962. But it also provides a strong message about the future of island nation. “Given what the Marshall Islands has done for hu...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Asia-Pacific Development & Aid Editors' Choice Featured Headlines Health Human Rights Population Regional Categories TerraViva United Nations Hansen's disease leprosy Marshall Islands Nippon Foundation Sasakawa Health Fou Source Type: news
Emerging/re-emerging viral diseases &new viruses on the Indian horizon. Indian J Med Res. 2019 Apr;149(4):447-467 Authors: Mourya DT, Yadav PD, Ullas PT, Bhardwaj SD, Sahay RR, Chadha MS, Shete AM, Jadhav S, Gupta N, Gangakhedkar RR, Khasnobis P, Singh SK Abstract Infectious diseases remain as the major causes of human and animal morbidity and mortality leading to significant healthcare expenditure in India. The country has experienced the outbreaks and epidemics of many infectious diseases. However, enormous successes have been obtained against the control of major epidemic diseases, such as mala...
Source: The Indian Journal of Medical Research - Category: Biomedical Science Authors: Tags: Indian J Med Res Source Type: research
[Update of knowledge on Neglected Diseases in Haiti: Mansonelliasis, Tungiasis, Leprosy, and Anthrax]. Bull Soc Pathol Exot. 2018;111(1):17-23 Authors: Raccurt CP, Boncy J, Jean-Baptiste RMA, Honoré R, Andrecy LL, Dély P, Mondésir L, Chatelier M, Existe A, Adrien P Abstract Haiti, like most limited-resources countries in the world, faces numerous neglected infectious diseases. They represent a real public health issue with lethal consequences especially in children. We are reviewing here the available literature on four neglected infectious diseases, mansonelliasis, tungi...
Source: Bulletin de la Societe de Pathologie Exotique - Category: Tropical Medicine Tags: Bull Soc Pathol Exot Source Type: research
This study aimed to evaluate how a CHW program for community treatment support and addressing socioeconomic barriers to care can impact patient outcomes in a post-conflict and post-epidemic context. METHODS: Retrospective observational study utilizing registry data from 513 TB, 447 HIV and 75 leprosy patients at three health facilities in Maryland County, Liberia. Treatment coverage and clinical outcomes for patient cohorts enrolled in the pre-intervention period (January 2015 to June 2015) and the post-intervention period (July 2015 to July 2017) are compared using logistic regression analyses. RESULTS: TB treatme...
Source: Global Health Action - Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research
Publication date: Available online 14 February 2018Source: EpidemicsAuthor(s): Thomas M. Lietman, Lee Worden, Fengchen Liu, Travis C. PorcoAbstractMathematical models predict that the community-level incidence of a controlled infectious disease across a region approaches a geometric distribution. This could hold over larger regions, if new cases remain proportional to existing cases. Leprosy has been disappearing for centuries, making an excellent candidate for testing this hypothesis. Here, we show the annual new case detection rate of leprosy in Indian districts to be consistent with a geometric distribution. For 2008&nd...
Source: Epidemics - Category: Epidemiology Source Type: research
Authors: Sykes IJ Abstract Medicine and religion worked in close synchronisation during the leprosy outbreak of New Caledonia (1890-1950). Once isolation of leprosy-affected people became mandatory doctors and missionaries came together to promote a particular form of medical practice that tied charitable zeal with cutting-edge medical research, developing a sophisticated set of medical practices that catered for the soul as well as the body. Such practices went hand-in-hand with ideas developed by doctors in the earlier stages of the epidemic about the way in which the disease had entered the Kanak (local Melanesi...
Source: Anthropology and Medicine - Category: International Medicine & Public Health Tags: Anthropol Med Source Type: research
Squirrels might have caused or maintained an epidemic of leprosy in medieval England. Genetic analysis of Mycobacterium leprae from a pre-Norman skull found in a garden in Suffolk has lent support to the suggestion that East Anglia was the epicentre of the medieval leprosy epidemic. The M leprae strain found on the skull matches the strain found on skeletal remains from medieval Denmark and Sweden. The bacteria might have arrived on the east coast of England along viking trade routes for the then-popular squirrel meat and fur.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Newsdesk Source Type: research
Abstract Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis ( P. brasiliensis ) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii ( P. lutzii ), has been reporte...
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
(St John's College, University of Cambridge) Genetic analysis of a pre-Norman skull unearthed in a garden in Suffolk has added to a growing body of evidence that East Anglia may have been the epicentre of an epidemic of leprosy that spread through medieval England. The authors of the new study suggest that an explanation for the prevalence of leprosy in medieval East Anglia may possibly be found in the sustained Scandinavian trade in squirrel fur -- an animal known to carry the disease.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
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