Long-Term Outcomes with 3-Dimensional Conformal External Beam Accelerated Partial Breast Irradiation

ConclusionsExternal beam APBI results in excellent long-term disease control. Good to excellent cosmetic outcomes are achieved in most patients, although increasing dose per fraction and greater percentage of irradiated breast were predictive of adverse posttreatment cosmetic outcomes. Select patients in “cautionary” and “unsuitable” consensus groupings do not appear to have inferior outcomes.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

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ConclusionThe surgical treatment of postirradiation kyphotic spinal deformity is challenging, with common postoperative complications such as infection, instrumentation failure, and pseudarthrosis. However, with modern surgical techniques and spinal instrumentation, excellent deformity correction can be achieved and maintained. We recommend performing a two-stage procedure for cervicothoracic deformity, with anterior release followed by posterior fusion and instrumentation. In thoracolumbar deformities, correction can be achieved through single-stage posterior fusion. Rigid spinopelvic fixation with sacral-alar-iliac screw...
Source: Spine Deformity - Category: Orthopaedics Source Type: research
ConclusionIORT boost appears to be a  highly efficient and safe method for upfront delivery of the tumor bed boost in high-risk breast cancer patients.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
ConclusionExternal beam APBI results in excellent long-term disease control. Good-to-excellent cosmetic outcomes are achieved in most patients, although increasing dose per fraction as well as greater percentage of irradiated breast were predictive of adverse post-treatment cosmetic outcomes. Select patients in “cautionary” and “unsuitable” consensus groupings do not appear to have inferior outcomes.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Abstract Radiation dermatitis is a common adverse effect of radiotherapy (RT) in breast cancer patients. Although radiation dermatitis is reported by either the clinician or the patient, previous studies have shown disagreement between clinician-reported outcomes (CROs) and patient-reported outcomes (PROs). This review evaluated the extent of discordance between CROs and PROs for radiation dermatitis. Studies reporting both clinician and patient-reported outcomes for external beam RT were eligible. Nine studies met the inclusion criteria for the systematic review, while 8 of these studies were eligible for inclusi...
Source: Breast - Category: Cancer & Oncology Authors: Tags: Breast Source Type: research
Pain originating from uncomplicated bone metastases, defined as those which have not resulted in and are not at imminent risk for pathological fracture or spinal cord compression, is effectively palliated by conventional external beam radiation therapy (RT) [1,2]. There has been a long-standing debate regarding the efficacy of single fraction (SFRT) compared to multiple fraction RT (MFRT); many systematic reviews and meta-analyses have been conducted to date to try to resolve the debate [3 –5]. More recent reviews by Chow et al.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Conclusions: Ga-68 DOTATOC PET/CT has a significant impact on management of patients with NETs, similar to Ga-68 DOTATATE PET/CT.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrinology (Clinical Therapy) Posters Source Type: research
The spine is the most frequent location of bone metastases. Local treatment aims at palliation of pain and, given the increased likelihood of long-term cancer survival, at local control. Kyphoplasty and intrao...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Study protocol Source Type: research
Conclusions The recent, first randomized clinical trial demonstrated overall and progression free survival benefits after SBRT to oligometastatic disease which supports prior retrospective case series (6). The spine is a common site of metastatic bone disease, and as high quality data continue to mature, along with completion of additional randomized clinical trials, it is expected that utility of SBRT to the spine will increase in the future. Spine SBRT is unique due to the requirement of sharp dose falloff to prevent serious neurologic morbidity. With recent advances in radiotherapy planning, robotic patient positionin...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
We present a 54-year-old male patient admitted to our clinic, complaining about having back pains for approximately three months. A lumbosacral spine MRI and a PET/CT scan revealed multiple lesions in the L4, L5, S1 vertebra bodies, sacral bone and left pelvis bone, suggesting of a metastatic disease. The result of thyroid FNA was carcinoma and a biopsy of the vertebra bone confirmed the presence of a metastatic carcinoma. A total thyroidectomy and level VI neck dissection was conducted followed by palliative external beam radiotherapy (30 Gy) to the vertebra bodies, sacral bone and left pelvis bone. In pathological studie...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
kiewicz The majority of advanced cancer patients suffer from pain, which severely deteriorates their quality of life. Apart from analgesics, bisphosphonates, and invasive methods of analgesic treatment (e.g., intraspinal and epidural analgesics or neurolytic blockades), radiation therapy plays an important role in pain alleviation. It is delivered to a growing primary tumour, lymph nodes, or distant metastatic sites, producing pain of various intensity. Currently, different regiments of radiation therapy methods and techniques and various radiation dose fractionations are incorporated into the clinical practice. These ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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