Precision oncotherapy based on liquid biopsies in multidisciplinary treatment of unresectable recurrent rectal cancer: a retrospective cohort study

ConclusionsThe present data indicate that in URCC patients, the integration of HPP/target-therapy and precision oncotherapy based upon liquid biopsy is as effective and efficacious as third-line treatment in local disease control and, therefore, deserves to be further assessed and compared to conventional systemic treatments in future prospective randomized trials.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research

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ConclusionsThe development of a pelvic MRI curriculum for residents entering CGSO fellowships could enhance their clinical training in the multidisciplinary management of patients with rectal cancer.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsAn 11-point modified frailty index as measured in NSQIP correlates with readmissions after colorectal resection in patients with colon and rectal cancer.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Can Yi, Chao Huang, Huan Wang, Chen Wang, Lijuan Dong, Xiuli Gu, Xianhong Feng, Bifeng ChenAbstractCYP24A1, an essential gene in regulation of vitamin D, has been reported to play an important role in enhancing immune activity and inhibiting tumorigenesis. Previous studies proposed that rs2585428, rs4809960, rs6022999 and rs6068816 in CYP24A1 gene might be greatly associated with cancer risk. To validate the findings, we here investigated the associations of these four polymorphisms and colorectal cancer (CRC) risk in a c...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
No abstract available
Source: Annals of Surgery - Category: Surgery Tags: LETTERS AND REPLIES Source Type: research
No abstract available
Source: Annals of Surgery - Category: Surgery Tags: LETTERS AND REPLIES Source Type: research
No abstract available
Source: Annals of Surgery - Category: Surgery Tags: LETTERS AND REPLIES Source Type: research
Conclusions: High-quality TME for patients with rectal adenocarcinoma of the mid and low rectum can be equally achieved by transanal or robotic approaches in skilled hands, but attention should be paid to the distal margin.
Source: Annals of Surgery - Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research
ConclusionR-TME for rectal cancer can achieve better oncological outcomes compared with L-TME, especially in stage III rectal cancers. However, a longer follow-up period is needed to confirm these findings.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionOur findings suggest that tumor progression accompanied by a high stage, long operative time, and insufficient bowel preparation and early postoperative diarrhea due to a large tumor circumference may be risk factors of AL after LALAR for rectal cancer.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
Rectal cancers account for 39% of colorectal tumours, and represent the 8th most common malignancy and the 9th leading cause of cancer-related deaths [1]. In 2018, 704,376 new diagnoses and 310,394 deaths for this disease were registered worldwide [1]. The global distribution of rectal cancer is characterised by some geographic variation with incidence rates being higher in Eastern Europe, Australia/New Zealand and Eastern Asia while lower in most African regions and Southern Asia [1]. Rectal cancers are the most common colorectal tumour among people
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Systematic or Meta-analysis Studies Source Type: research
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