Prediction of Hypoxia in Brain Tumors Using a Multivariate Model Built from MR Imaging and 18F-Fluorodeoxyglucose Accumulation Data.

CONCLUSION: A multivariate prediction model created using blood flow, vascular permeability, and glycometabolism parameters can predict the extent of hypoxia in FMISO-positive areas in patients with brain tumors. PMID: 31611541 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medical Sciences : MRMS - Category: Radiology Authors: Tags: Magn Reson Med Sci Source Type: research

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Abstract13N-Ammonia (13N-NH3) is widely used positron emission tomography/computed tomography (PET/CT) radiotracer for the measurement of myocardial blood perfusion; the possible role of13N-NH3 PET or PET/CT in oncological disease is not yet clear. Aim of this review is to evaluate the diagnostic performances of13N-NH3 PET in this field. A comprehensive computer literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted including articles up to June 2019. Eighteen articles were finally included in the review. From the analyses of the selected studies, the following main findings could be drawn: (1)...
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
This article provides a brief discussion of the major 2016 updates to the WHO CNS classification scheme and reviews typical MR imaging findings of adult primary CNS neoplasms, including diffuse infiltrating gliomas, ependymal tumors, neuronal/glioneuronal tumors, pineal gland tumors, meningiomas, nerve sheath tumors, solitary fibrous tumors, and lymphoma. PMID: 31582041 [PubMed - in process]
Source: Radiologic Clinics of North America - Category: Radiology Authors: Tags: Radiol Clin North Am Source Type: research
ConclusionsThe chromosomal translocation t(14;18)(q32;q21) forIgH/BCL2 was detected in central nervous system tumor ‐like inflammatory lesions. All patients responded well to the corticosteroid therapy and had a good prognosis. As the perivascular cells bearing t(14;18)(q32;q21) are small in number, the pathological significance remains unknown.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: Original Article Source Type: research
This article provides a brief discussion of the major 2016 updates to the WHO CNS classification scheme and reviews typical MR imaging findings of adult primary CNS neoplasms, including diffuse infiltrating gliomas, ependymal tumors, neuronal/glioneuronal tumors, pineal gland tumors, meningiomas, nerve sheath tumors, solitary fibrous tumors, and lymphoma.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
ConclusionsDynamic contrast ‐enhanced‐Magnetic resonance imaging is a promising noninvasive imaging method that has moderate or high accuracy in stratifying gliomas. DCE‐MRI shows high diagnostic accuracy in discriminating between HGGs and their low‐grade counterparts, and moderate diagnostic accuracy in discriminating recurrent lesions and treatment‐related changes as well as PCNSLs and HGGs.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSIONS: Due to the relatively few number or clinical studies, prospective clinical trials are needed to increase the overall level of evidence concerning the usage of 5-ALA in CNS tumors different from high-grade glioma. Furthermore, a greater us of new tools such as, spectroscopy or confocal microscope or the use of combination of other fluorescence could make more effective this technique. PMID: 31355622 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
The aim of this review was to review the basic background, technique, and clinical applications of arterial spin labeling in brain tumors. Arterial spin labeling is used for differentiation of brain tumors from nonneoplastic lesions such as infarction and infection. It has a role in the grading of gliomas and in the differentiation of gliomas from lymphomas and metastasis. It is used for detection of the best biopsy site and prediction of treatment response. Arterial spin labeling is used for the assessment of extra-axial tumors and pediatric tumors. Last, it has a role in the differentiation of tumor recurrence from postr...
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Neuroradiology Source Type: research
328Purpose: To prospectively determine whether differences between benign and malignant lesions in brain and neck can be depicted with 18F-(2S, 4R) 4-fluoroglutamine (18F-FGln) PET. Materials and Methods: 24 patients (14 women, 10men; age range, 26-79 years) with solitary brain lesions that were enhanced at magnetic resonance (MR) imaging underwent dynamic or static whole-brain 18F-FGln PET/CT after giving informed consent in this institutional review board-approved. Histopathologic diagnoses were made in all cases (9 high-grade gliomas, 9 metastases to the brain, 2 primary brain lymphoma and 4 benign lesions). In four ben...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Brain Imaging Targets Source Type: research
Conclusions: The absence of CXCR4 tumor imaging in the two brain tumor models with 76Br HZ270 1 is largely due to the hydrophilicity of the radiolabeled bicyclam analogues (based on the measured octanol/water partition coefficient, LogP), in contrast to the structure based estimate of LogP and to the presence of an intact BBB and BTB in the animal intracranial tumor models.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiochemistry & amp; Chelation Posters Source Type: research
Antonio Lucena-Cacace1, Masayuki Umeda1, Lola E. Navas2,3 and Amancio Carnero2,3* 1Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan 2CIBERONC, ISCIII, Madrid, Spain 3Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío (HUVR), CSIC, Universidad de Sevilla, Sevilla, Spain Glioma Cancer Stem-Like Cells (GSCs) are a small subset of CD133+ cells with self-renewal properties and capable of initiating new tumors contributing to Glioma progression, maintenance, hierarchy, and complexity. GSCs are highly res...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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