I can't drink what I used to: The interaction between ethanol and the aging brain

Publication date: Available online 15 October 2019Source: International Review of NeurobiologyAuthor(s): Douglas B. Matthews, Amelia Schneider, Abigail Kastner, Samantha Scaletty, Rachel SzenayAbstractThe population of most countries is increasing and the United Nations predicts that by the year 2050 those over the age of 60 years old will increase from 900 million individuals to approximately 2.1 billion individuals (United Nations, 2015). The increase in the number of older individuals will place a strain on many national health care systems making it important to investigate behaviors in the aged that may negatively impact general health in this demographic. Recent work has shown that older adults consume alcohol, often at levels that exceed the legal limit of intoxication. Unfortunately, consumption of high levels of ethanol in the older population is associated with many health consequences and may negatively impact the brain. Given ethical constraints found in many biomedical studies, animal models are needed to investigate the possible negative impact of high ethanol use in aged populations. However, few studies have investigated the effect of ethanol exposure in aged animals compared to ethanol exposure in younger animals and consequently the impact of ethanol in the aged population is not well understood.The current review summarizes initial work establishing the impact of ethanol in aged animals. The reviewed research studies support the working hypothesis that etha...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research

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Publication date: Available online 18 November 2019Source: Innovative Food Science &Emerging TechnologiesAuthor(s): Marina Al Daccache, Mohamed Koubaa, Dominique Salameh, Eugène Vorobiev, Richard G. Maroun, Nicolas LoukaAbstractThe effect of moderate pulsed electric fields (PEF) on Hanseniaspora sp. fermentations in apple juice was examined. The treatments were applied prior to or during the fermentation using a field strength of 285 V/cm. A significant increase (p 
Source: Innovative Food Science and Emerging Technologies - Category: Food Science Source Type: research
Worsening nausea, vomiting, and dizziness for 2-months, resulting in a 20-pound weight loss. Pruritus. Ataxia. Mild hearing loss, with reoccurring episodes of falls. Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
This study tested whether electrical stimulation of the pharyngeal mucosa is able to induce reliably the swallowing reflex in awake and asleep obstructive sleep apnea (OSA) patients, and whether the induced reflexes affect the sleep variables. In addition, the latency, occurrence, and morphology of swallows were evaluated. Eight patients received an esophageal catheter that was used on three consecutive nights for electrical stimulation and manometric recordings. The electrical stimulation proved itself safe, but its efficiency in inducing swallows sank from 80.0% in awake to 37.4% in sleeping subjects and was lowest in th...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
CONCLUSION: As it is detected by a survey performed by telephone calls with good interrater reliability, patients with PD gets better with LCIG treatment in many aspects of the disease. PMID: 31731332 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Douglas B. Matthews, Amelia Schneider, Abigail Kastner, Samantha Scaletty, Rachel SzenayAbstractThe population of most countries is increasing and the United Nations predicts that by the year 2050 those over the age of 60 years old will increase from 900 million individuals to approximately 2.1 billion individuals (United Nations, 2015). The increase in the number of older individuals will place a strain on many national health care systems making it important to investigate behaviors in the aged that may negatively impact general heal...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
ConclusionsDifferent patterns of sleep disturbances are observed in HD patients: insomnia, difficulties in falling asleep, frequent nocturnal awakenings, and excessive daytime sleepiness are the most common sleep problems reported by patients with HD. In several HD studies, specific changes in sleep architecture and in circadian melatonin secretion were identified in laboratory testing.Sleep disorders in HD have diverse and complex determinants, the most significant of which includes damage to brain areas that are responsible for the proper sleep pattern and circadian rhythm regulation. Sleep and circadian rhythm disorders...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study indicated that switch from H2 blockers to PPIs reduced delirium and, thus, providing an appropriate strategy to combat drug-induced delirium using antiulcer drugs (Fujii et al., 2012). The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep and augment the firing rate of neurons in ventrolateral GABAergic preoptic nucleus, but the underlining mechanism is yet to be clearly determined. Interestingly, the propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibite...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Discussion Headache is pain in the scalp, forehead, orbits and temple. Facial and neck pain are usually excluded from this definition. It is a common problem with more than 6 million pediatric patients having migraine. Headaches can also have co-morbidities and more than 1 primary headache type can co-exist. The costs are high both economically and in the quality of life for the patients and families. A review of common headache types and indications for neuroimaging can be found here. Treatment is necessarily multi-pronged. Patients should understand their diagnosis so they can understand what reasonably can be expected...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Conclusions:Intake of herbal supplements has increased over the past decade warranting an extensive medication history as part of a full neurological evaluation. Clinicians should be wary of rare causes like chronic heavy metal exposure in patients with unexplained neurological symptoms.Disclosure: Dr. Grewal has nothing to disclose. Dr. Nanjundaswamy has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: General Neurology: Ataxia, Spasticity, and Gait Disorders Source Type: research
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disease with motor, psychiatric, and cognitive manifestations that occurs in carriers of the fragile X mental retardation 1 (FMR1) gene premutations. This was a retrospective chart review of 196 individuals (127 men and 69 women) with FXTAS. Forty-six (23%) participants were cognitively impaired, of whom 19 (10%) had dementia. Risk factors for dementia were examined (CGG repeat size; alcohol, benzodiazepine, and opioid use; diabetes; hyperlipidemia; hypertension; hypothyroidism; obesity; sleep apnea; surgeries with general anesthesia; dep...
Source: Journal of Geriatric Psychiatry and Neurology - Category: Genetics & Stem Cells Authors: Tags: Articles Source Type: research
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