Analysis in a murine model points to IgG responses against the 34k2 salivary proteins from < i > Aedes albopictus < /i > and < i > Aedes aegypti < /i > as novel promising candidate markers of host exposure to < i > Aedes < /i > mosquitoes

Conclusions/significanceOur study shows that exposure to bites ofAe.albopictus orAe.aegypti evokes in mice species-specific IgG responses to al34k2 or ae34k2, respectively. Deeper understanding of duration of antibody response and validation in natural conditions of human exposure toAedes mosquitoes are certainly needed. However, our findings point to the al34k2 salivary protein as a promising potential candidate for the development of immunoassays to evaluate human exposure toAe.albopictus. This would be a step forward in the establishment of a serological toolbox for the simultaneous assessment of human exposure toAedes vectors and the pathogens they transmit.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research