Bacterial survival in whole blood depends on plasma sensitivity and resistance to neutrophil killing.

CONCLUSIONS: The bactericidal activity of WB can be the result of plasma sensitivity or neutrophil killing. Bacteria with a starting inoculum of 500 CFU/mL, and able to resist WB immune factors, can proliferate to clinically significant levels posing a potential safety risk to transfusion patients. Results of this pilot study should be validated under standard WB collection and storage conditions. PMID: 31608457 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31608457?dopt=Abstract

Source: Transfusion - October 12, 2019 Category: Hematology Authors: Taha M, Kyluik-Price D, Kumaran D, Scott MD, Toyofuku W, Ramirez-Arcos S Tags: Transfusion Source Type: research