Scaffold-free endometrial organoids respond to excess androgens associated with polycystic ovarian syndrome.

CONCLUSIONS: A new multicellular, scaffold-free endometrial organoid system was established that resembled physiology of the native endometrium. Excess androgens in PCOS promoted cell proliferation in endometrial organoids, revealing new mechanisms of PCOS-associated with risk of endometrial neoplasia. PMID: 31614364 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31614364?dopt=Abstract

Source: The Journal of Clinical Endocrinology and Metabolism - October 15, 2019 Category: Endocrinology Authors: Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ Tags: J Clin Endocrinol Metab Source Type: research