Indirect costs of adult pneumococcal disease and productivity-based rate of return to PCV13 vaccination for older adults and elderly diabetics in Denmark

Publication date: 2019Source: The Journal of the Economics of Ageing, Volume 14Author(s): J.P. Sevilla, Andrew Stawasz, Daria Burnes, Peter Bo Poulsen, Reiko Sato, David E. Bloom
Source: The Journal of the Economics of Ageing - Category: Health Management Source Type: research

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ConclusionAdults who received pneumococcal vaccines experienced reduced rates of hospital versus ICU admissions due to pneumonia infection.
Source: Journal of Pharmaceutical Health Services Research - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
Different abnormalities account for the increased risk of viral and bacterial infection in patients with diabetes mellitus (DM). Main irregularities include: decreased CD4/CD8 lymphocyte ratios, reduced monocyte phagocytic function and defects in interleukin-2 production [1 –6]. Individuals with DM are 6 time more likely to be hospitalized and 3 times more likely to die from complications of influenza or pneumonia when compared to those in general population [7]. People with DM have higher rates of hepatitis B due to contact with infected blood or through improper eq uipment use (glucose monitoring devices or infected needles) [8].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Publication date: Available online 8 August 2019Source: The Journal of the Economics of AgeingAuthor(s): JP Sevilla, Andrew Stawasz, Daria Burnes, Peter Bo Poulsen, Reiko Sato, David Bloom
Source: The Journal of the Economics of Ageing - Category: Health Management Source Type: research
CONCLUSION: Based on this information, future programs aimed at people aged
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
AbstractObjectivesTo evaluate predictors of serious infections events (SIEs) during rituximab (RTX) therapy and effects of hypogammaglobulinaemia concerning SIE rates, humoral response and its persistence post ‐RTX discontinuation in the treatment of rheumatic and musculoskeletal diseases (RMDs).MethodsA retrospective longitudinal study was conducted in a single centre in 700 RTX ‐treated RMD patients. Immunoglobulins were measured at baseline and 4–6 months after each cycle. Baseline predictors of SIEs were assessed using multivariable logistic regression; for cycles 2‐4 mixed‐effects logistic regression wer...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
CONCLUSIONS: After implementation of a pneumococcal conjugate vaccination program in US children, and despite the herd protection observed in US adults, a persistent burden of PCV13-type CAP remains in this population. PMID: 31072732 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conclusion: The results suggest that an immunosuppressive state develops at the terminal stage of severe leptospirosis with pulmonary hemorrhage and shock similar to that of patients with septic shock, with diffuse endothelial activation in the spleen, splenitis, and signs of disturbance in the innate and adaptive immunity in the spleen. The presence of leptospiral antigens in 73% of the spleens of the leptospirosis patients suggests the etiological agent contributes directly to the pathogenesis of the lesions. Our results support therapeutic approaches involving antibiotic and immunomodulatory treatments for leptospirosis...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Parvaiz A Koul, Sudhir Chaudhari, Ramesh Chokhani, D Christopher, Raja Dhar, Kumar Doshi, A Ghoshal, SK Luhadiya, Ashok Mahashur, Ravindra Mehta, Amita Nene, Md Rahman, Rajesh SwarnakarLung India 2019 36(3):216-225 Globally, pneumococcal diseases are a significant public health concern. They are preventable and frequently occur among older adults. Major risk factors for the disease are extremes of age, alcohol intake, smoking, air pollution, and comorbid conditions (diabetes, chronic obstructive pulmonary disease, chronic kidney disease, liver disease, and heart disease). Risk factors, coupled with limited disease-burden ...
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
In conclusion, we unraveled the secretome of G. adiacens, an oral bacterium well-documented in infective endocarditis, but also recently shown to be involved in oral infections. Importantly, the secretome of G. adiacens comprised of a large number of putative virulence factors. Of particular importance is the finding that the G. adiacens secretome comprised of a number of “moonlighting” proteins, which in other species are shown to enhance bacterial colonization and virulence through their multifunctional roles (Pavkova et al., 2017; Graf et al., 2019). Thus, our results provide a basis for investigating the ro...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Publication date: Available online 19 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Junichi Ishigami, William V. Padula, Morgan E. Grams, Alexander R. Chang, Bernard Jaar, Ron T. Gansevoort, John F.P. Bridges, Csaba P. Kovesdy, Shinichi Uchida, Josef Coresh, Kunihiro MatsushitaRationale &ObjectivePneumococcal vaccine is recommended for adults 65 years and older and those younger than 65 years with clinical indications (eg, diabetes, lung/heart disease, kidney failure, and nephrotic syndrome). Its cost-effectiveness in less severe chronic kidney disease (CKD) is uncharacterized.Study DesignCost-effecti...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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