Non-invasive evaluation of GPR119 agonist effects on β-cell mass in diabetic male mice using 111In-exendin-4 SPECT/CT.

In this study, we used the 111In-exendin-4 single-photon emission computed tomography/computed tomography (SPECT/CT) technique to investigate the efficacy of DS-8500a, a novel G protein-coupled receptor 119 agonist currently under investigation for T2DM treatment, in prediabetic db/db mice under dietary restriction. During the 8-week study, treatment of mice with DS-8500a delayed and attenuated the progression of glucose intolerance compared to mice under dietary restriction alone. 111In-exendin-4 SPECT/CT of db/db mice revealed continuously decreasing RI intensity in the pancreas over the 8-week intervention. DS-8500a attenuated this decrease and preserved pancreatic RI accumulation compared with dietary restriction alone at the end of the observation period. This result was corroborated not only by ex vivo pancreatic analysis using the [Lys12(111In-BnDTPA-Ahx)]exendin-4 probe but also by conventional histological BCM analysis. These results indicate that DS-8500a attenuates the progression of BCM loss beyond that of dietary restriction alone in prediabetic db/db mice. 111In-exendin-4 SPECT/CT will be useful for non-invasive longitudinal investigation of BCM in vivo. PMID: 31613319 [PubMed - as supplied by publisher]
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research

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Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
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Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
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