Histamine Modulation of Acute Nociception Involves Regulation of Nav 1.8 in Primary Afferent Neurons in Mice.

CONCLUSION: Our results indicate that histamine participates in acute pain modulation in a dose-related manner. The regulation of Nav 1.8 expression and the excitability of nociceptive primary afferent neurons may be involved in the underlying mechanisms. PMID: 23773488 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23773488?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - June 15, 2013 Category: Neuroscience Authors: Yu J, Fang Q, Lou GD, Shou WT, Yue JX, Tang YY, Hou WW, Xu TL, Ohtsu H, Zhang SH, Chen Z Tags: CNS Neurosci Ther Source Type: research