Canon debuts Alphenix version for labs and centers

Canon Medical Systems USA has introduced Alphenix Aero Edition, a new interventional...Read more on AuntMinnie.comRelated Reading: Canon plans to open Middle East division Canon unveils Alphenix Encore Plus Program Canon's CT portfolio primed for lung cancer screening Canon installs 3T MRI scanner in Colo. Canon makes 1st Alphenix Core+ install in Fla.

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Source: AuntMinnie.com Headlines - October 16, 2019 Category: Radiology Source Type: news

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Metabolic Responses to Metformin in Inoperable Early-stage Non–Small Cell Lung Cancer Treated With Stereotactic Radiotherapy: Results of a Randomized Phase II Clinical Trial

Conclusions: Despite low accrual, majority of subjects treated with metformin had metabolic responses by PERCIST criteria on PET imaging. Contrary to the effect of metformin on most physiologic tissues, most tumors had increased metabolic activity in response to metformin.

Source: American Journal of Clinical Oncology - March 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Radiomics of 18 F-FDG PET/CT images predicts clinical benefit of advanced NSCLC patients to checkpoint blockade immunotherapy

ConclusionPET/CT-based signature can be used prior to initiation of immunotherapy to identify NSCLC patients most likely to benefit from immunotherapy. As such, these data may be leveraged to improve more precise and individualized decision support in the treatment of patients with advanced NSCLC.

Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

New insight on the correlation of metabolic status on 18 F-FDG PET/CT with immune marker expression in patients with non-small cell lung cancer

AbstractBackgroundMetabolic information obtained through18F-flurodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is used to evaluate malignancy by calculating the glucose uptake rate, and these parameters play important roles in determining the prognosis of non-small cell lung cancer (NSCLC). The expression of immune-related markers in tumor tissue reflects the immune status in the tumor microenvironment. However, there is lack of reports on the association between metabolic variables and intra-tumor immune markers. Herein, we investigate the correlation between metabolic status on18F-FDG PET...

Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Influx rate constant of 18 F-FDG increases in metastatic lymph nodes of non-small cell lung cancer patients

AbstractPurposePrimary tumor (PT) and metastatic lymph node (MLN) status have a great influence on diagnosis and treatment of lung cancer. Our main purpose was to investigate the imaging characteristics of PT or MLN by applying the18F-FDG PET dynamic modeling approach for non-small cell lung cancer (NSCLC).MethodsDynamic18F-FDG PET scans were performed for 76 lung cancer patients, and 62 NSCLC cases were finally included in this study: 37 with newly diagnosed early and locally advanced lung cancer without distant metastases (group M0) and 25 metastatic lung cancer (group M1). Patlak graphic analysis (Ki calculation) based ...

Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

How to reduce lung cancer mortality among people living with HIV?

Authors: Ruppert AM, Lavolé A, Makinson A, Le Maître B, Cadranel J Abstract Lung cancer is the leading cause of cancer related death among people living with HIV (PLHIV). Tobacco exposure is higher among PLHIV (38.5%) and mainly explains the increased risk of lung cancer. To reduce lung cancer mortality, two approaches need to be implemented: lung cancer screening with low-dose thoracic CT scan and smoking cessation. Low dose CT scan is feasible in PLHIV. The false positive rate is not higher than in the general population, except for cases with CD4

Source: Revue des Maladies Respiratoires - March 22, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Radiotherapy planning and Molecular Imaging in Lung Cancer.

Authors: Filice A, Casali M, Ciammella P, Galaverni M, Fioroni F, Lotti C, Versari A Abstract The goal of the radiotherapy (RT) planning process is to select and delineate target volumes with the best accuracy on the basis of all the available diagnostic information and the knowledge of the physiology of the disease. The recommendation of the International Atomic Energy Agency (IAEA) expert panel, is that an appropriately timed and technically adequate 2-[18F]fluoro-2-deoxy-d-glucose/Positron Emission Tomography-Computer Tomography (18F-FDG-PET/CT) imaging is an essential component in the radiotherapy treatment pla...

Source: Current Radiopharmaceuticals - March 20, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

AI may help predict responses to non-small cell lung cancer systemic therapies

(American Association for Cancer Research) Using standard-of-care computed tomography (CT) scans in patients with advanced non-small cell lung cancer (NSCLC), researchers utilized artificial intelligence (AI) to train algorithms to predict tumor sensitivity to three systemic cancer therapies.

Source: EurekAlert! - Cancer - March 20, 2020 Category: Cancer & Oncology Source Type: news

PET and CT Underutilized in Blacks, Hispanics at Lung-Cancer Diagnosis PET and CT Underutilized in Blacks, Hispanics at Lung-Cancer Diagnosis

Blacks and Hispanics are less likely to undergo guideline-recommended PET and CT scans at diagnosis of non-small-cell lung cancer (NSCLC), according to a database study.Reuters Health Information

Source: Medscape Radiology Headlines - March 18, 2020 Category: Radiology Tags: Hematology-Oncology News Source Type: news

Radiomics study for predicting the expression of PD-L1 in non-small cell lung cancer based on CT images and clinicopathologic features.

CONCLUSION: The prediction model that incorporates the radiomics signature and clinical risk factors has potential to facilitate the individualized prediction of PD-L1 expression in NSCLC patients and identify patients who can benefit from anti-PD-L1 immunotherapy. PMID: 32176676 [PubMed - as supplied by publisher]

Source: Journal of X-Ray Science and Technology - March 18, 2020 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Stereotactic radiosurgery combined with anlotinib for limited brain metastases with perilesional edema in non ‐small cell lung cancer: Rvision‐001 study protocol

This study is a multicenter, prospective, single ‐arm, phase II clinical study, and explores the efficacy and tolerability of SRS with anlotinib in NSCLC patients with limited brain metastases. The aim of the study is to provide new treatment options for NSCLC patients with brain metastases.

Source: Thoracic Cancer - March 16, 2020 Category: Cancer & Oncology Authors: Yuxia Wang, Xin Wang, Yun Guan, Yongchun Song, Hongqing Zhuang, Enmin Wang Tags: STUDY PROTOCOL Source Type: research