Influence of Obesity, Weight Loss, and Free Fatty Acids on Skeletal Muscle Clock Gene Expression.
In conclusion, skeletal muscle clock gene expression and function is altered by obesity, coincident with changes in plasma lipid levels. Palmitate exposure disrupts clock gene expression in myotubes, indicating dyslipidemia directly alters the circadian program. Strategies to reduce lipid overload and prevent elevations in NEFA and cholesterol levels may sustain circadian clock signals in skeletal muscle.
PMID: 31613643 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Sardon Puig L, Pillon NJ, Näslund E, Krook A, Zierath JR Tags: Am J Physiol Endocrinol Metab Source Type: research
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