Nanoparticle-mediated drug delivery: blood-brain barrier as the main obstacle to treat infectious diseases in CNS.

CONCLUSIONS: The scarcity of the studies trying to understand the compatibility as well as the exact mechanisms by which NDDS might be serving to enter the CNS infected by parasites opens new possibilities for further exploratory projects. There is an urgent need for new investments and motivations in the area of nanotechnology applied to the control of parasitic infectious diseases worldwide. PMID: 31612822 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

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Charlotte Clarkson, 24, a nanny from Edinburgh, was left blind in one eye after a minuscule waterborne parasite called acanthamoeba burrowed into her right cornea, the clear front part of the eye.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Acanthamoeba spp. are cosmopolitan protozoans that cause infections in the brain, as well as extracerebral infections in the cornea, lungs and skin. Little is known about the mechanisms of the immunological respo...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
The encystation of Acanthamoeba leads to the development of resilient cysts from vegetative trophozoites. This process is essential for the survival of parasites under unfavorable conditions. Previous studies hav...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Abstract Acanthamoeba spp. are free living amoeba (FLA) which are widely distributed in nature. They are opportunistic parasites and can cause severe infections to the eye, skin and central nervous system. The advances in drug discovery and modifications in the chemotherapeutic agents have shown little improvement in morbidity and mortality rates associated with Acanthamoeba infections. The mechanism-based process of drug discovery depends on the molecular drug targets present in the signaling pathways in the genome. Synthetic libraries provide a platform for broad spectrum of activities due to their desired struc...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Abstract Free-living amoebae (FLA) including Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris are among the many waterborne parasites. There is not much known about the possible FLA contamination of the irrigation resources watering crops and agricultural lands in this country. Forty-five water samples were collected from water canals used for irrigation of farmlands and tested for the presence of pathogenic FLA using morphological and molecular-based methodology. The ITS region of Naegleria species was sequenced and a phylogenetic tree was generated to confirm the genetic associations and taxonom...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
Authors: Mitsuwan W, Bunsuwansakul C, Leonard TE, Laohaprapanon S, Hounkong K, Bunluepuech K, Chalermpol K, Mahboob T, Sumudi Raju C, Dhobi M, Pereira ML, Mohammad N, Wiart C, Siyadatpanah A, Norouzi R, Nissapatorn V Abstract Curcuma longa (C. longa) rhizome extract has been traditionally used to treat many infections. Curcumin, a pure compound isolated from the plant, has been documented to possess a wide spectrum of pharmacological effects. The present study aimed to investigate the effects of Thai medicinal plant extracts including C. longa extract and Curcumin on Acanthamoeba triangularis, a causative agent of ...
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
CONCLUSION: These extracts are not promising candidates for further medicine development on acanthamoebiasis. Nonetheless, further researches are necessary to clarify effective fractions of seed and leaf extracts of R. obtusifolius and their mechanisms of action. PMID: 32321413 [PubMed - as supplied by publisher]
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
This study demonstrated that the swimming pools and hot tub water in Qazvin province were contaminated with Acanthamoeba and Naegleria species. PMID: 32300097 [PubMed - in process]
Source: Journal of Water and Health - Category: Environmental Health Tags: J Water Health Source Type: research
by Gretchen Ehrenkaufer, Pengyang Li, Erin E. Stebbins, Monica M. Kangussu-Marcolino, Anjan Debnath, Corin V. White, Matthew S. Moser, Joseph DeRisi, Jolyn Gisselberg, Ellen Yeh, Steven C. Wang, Ana Hervella Company, Ludovica Monti, Conor R. Caffrey, Christopher D. Huston, Bo Wang, Upinder Singh Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing a drug though clinical trials and to market. Identification of single compounds active against multiple parasitic pathogens could improve...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Acanthamoeba spp. are ubiquitous pathogens which cause granulomatous amoebic encephalitis and disseminated infection. Moreover, Acanthamoeba spp. infection of the cornea leads to Acanthamoeba keratitis. Our previ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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