A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth.

A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth.
Neoplasma. 2019 Oct 09;:
Authors: Zhang L, Gao L, Shao M, Sun GY
Abstract
Non-small cell lung cancer (NSCLC) is the most prevalent subtype of lung cancer histologically, and an increasing number of evidences have shown that long non-coding RNAs (lncRNAs) are involved in tumorigenesis during the past years. Here we found a long non-coding RNA, GATA2-AS1, repressed NSCLC cells proliferation via regulating GATA2. GATA2-AS1 gene is located at antisense strand of GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein at promoter region of GATA2 and then inhibits its transcription. Moreover, GATA2-AS1 is transcriptionally repressed by MYC in NSCLC cells. To conclude, our study discovered the role of lncRNA GATA2-AS1 in human non-small cell lung cancer growth thus providing a potential target for anti-lung cancer drugs.
PMID: 31607132 [PubMed - as supplied by publisher]

Source: Neoplasma - October 8, 2019 Category: Cancer & Oncology Authors: Zhang L, Gao L, Shao M, Sun GY Tags: Neoplasma Source Type: research