Choosing the Right Antifungal Agent in ICU Patients

AbstractFungi are responsible for around 20% of microbiologically documented infections in intensive care units (ICU). In the last decade, the incidence of invasive fungal infections (IFI), including candidemia, has increased steadily because of increased numbers of both immunocompromised and ICU patients. To improve the outcomes of patients with IFI, intensivists need to be aware of the inherent challenges. This narrative review summarizes the features of routinely used treatments directed against IFI in non-neutropenic ICU patients, which include three classes of antifungals: polyenes, azoles, and echinocandins. ICU patients ’ pathophysiological changes are responsible for deep changes in the pharmacokinetics of antifungals. Moreover, drug interactions affect the response to antifungal treatments. Consequently, appropriate antifungal dosage is a challenge under these special conditions. Dosages should be based on rena l and liver function, and serum concentrations should be monitored. This review summarizes recent guidelines, focusing on bedside management.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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This article summarizes the main epidemiological characteristics of tinea gladiatorum, new outbreaks that have been presented over the years, and theories about their transmission, diagnosis, treatment, and prophylactic measures.Recent FindingsDespite the controversy, recent studies defined that the transmission of tinea gladiatorum is by skin-to-skin contact and through fomites. Once the infection is acquired, it is difficult to control due to its rapid dissemination to other wrestlers, so great importance has been taken to prevention.SummaryDespite dermatophytosis still being considered as one of the major public health ...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
AbstractPurpose of the ReviewCandida albicans vulvovaginitis is one of the most frequent symptomatic infections in women and its incidence increases in reproductive age and pregnancy. Currently there are more specific and sensitive tests to identifyCandida species that are resistant to antifungal agents, such as PCR and MALDI TOF MS, in order to improve prognosis.Recent FindingsThe genusCandida is part of the microbiota in humans; however, many species can become pathogenic. Vulvovaginitis caused by non-albicansCandida are becoming very important due to their high levels of antifungal resistance, which makes treatment diff...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
AbstractPurpose of ReviewFungal infections account for significant morbidity and mortality in HIV-infected children particularly in developing countries where there is lack of skilled personnel and infrastructure to make the appropriate diagnosis. This is further compounded by poor availability and accessibility of the antifungals needed to treat these infections. The purpose of this review is to highlight the paucity of data on AIDS-related mycoses in the paediatric age group and make appropriate recommendations to address challenges associated with mycoses in this population.Recent FindingsThese infections are categorise...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
WARNING: GRAPHIC CONTENT Bethany, from North Carolina, says she contacted a fungal infection from a nail salon that was using the same dip powder for several customers.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion: Our results demonstrated clinical epidemiology of various Candida species from cutaneous candidiasis distributed in new molecular types with increasing importance of drug resistant of non-albicans Candida species. Our results showed that drug susceptibility and genetic variability of Candida species may be attributed to their clinical features and source of isolation. PMID: 31719957 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
Inflammatix's tests could quickly determine if the cause of sepsis or fevers is due to a bacterial, viral or fungal infection.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Contributors : Rui Wang ; Wei Zhang ; Xiaoye YangSeries Type : Expression profiling by high throughput sequencingOrganism : Arthrobotrys flagransPurpose: To identify the putative high pathogenicity for fungal infection of nematodes of the nematode-trapping fungus Duddingtonia flagrans, RNA-seq was used to examine the transcriptional responses in three stages with the treatment of extraction of Caenorhabditis elegans.Methods:mRNA of three interaction stages (0h, 12h, 48h) were generated by deep sequencing, in triplicate, using Illumina Hiseq platforme,and 125 bp paired-end reads were generated.Then raw reads were firstly pr...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Arthrobotrys flagrans Source Type: research
Fungal Keratitis (FK) is an infective keratopathy with extremely high blindness rate. The damaging effect of this disease is not only the destruction of corneal tissue during fungal infection, but also the cor...
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
P, Sanguinetti M Abstract The introduction of non-culture-based diagnostic techniques is revolutionizing the world of microbiological diagnosis and infection assessment. Fungi are no exception, and the introduction of biomarkers has opened up enormous expectations for better management of these entities. Biomarkers are diverse, their targets are also diverse and their evaluation has been done preferably in an individualized use and with deficient designs. Less is known about the value of the combined use of biomarkers and the impact of the negativity of two or more biomarkers on antifungal treatment decisions has...
Source: Revista Espanola de Quimioterapia - Category: Drugs & Pharmacology Authors: Tags: Rev Esp Quimioter Source Type: research
(American Phytopathological Society) A recent Molecular Plant-Microbe Interactions article studies chitin-binding proteins from a soilborne fungus (Verticillium nonalfalfae) that causes vascular wilt in plants. This fungus binds a particular protein (VnaChtBP) to chitin in order to abolish the host plant's chitin-triggered burst of reactive oxygen species and shield the fungus from being digested by the plant.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
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