Innate immune suppression after traumatic brain injury and hemorrhage in a juvenile rat model of polytrauma

Traumatic injury in children is known to cause immune suppression. Polytrauma involving a traumatic brain injury (TBI) may increase this degree of immune suppression, which increases the risk of developing nosocomial infections, potentially causing secondary brain injury and worsening patient outcomes. Despite the high prevalence of polytrauma with TBI in children, mechanisms of immune suppression following such injuries remain poorly understood. Here, we used a combined animal injury model of TBI and hemorrhage to assess immune function after polytrauma.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research