Reduction of Pseudomonas aeruginosa biofilm formation through the application of nanoscale vibration

Publication date: Available online 15 October 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Shaun N. Robertson, Peter G. Childs, Ayorinde Akinbobola, Fiona L. Henriquez, Gordon Ramage, Stuart Reid, William G. Mackay, Craig WilliamsBacterial biofilms pose a significant burden in both healthcare and industrial environments. With the limited effectiveness of current biofilm control strategies, novel or adjunctive methods in biofilm control are being actively pursued. Reported here, is the first evidence of the application of nanovibrational stimulation (nanokicking) to reduce the biofilm formation of Pseudomonas aeruginosa. Nanoscale vertical displacements (approximately 60 nm) were imposed on P. aeruginosa cultures, with a significant reduction in biomass formation observed at frequencies between 200 and 4000 Hz at 24 h. The optimal reduction of biofilm formation was observed at 1 kHz, with changes in the physical morphology of the biofilms. Scanning electron microscope imaging of control and biofilms formed under nanovibrational stimulation gave indication of a reduction in extracellular matrix (ECM). Quantification of the carbohydrate and protein components of the ECM was performed and showed a significant reduction at 24 h at 1 kHz frequency. To model the forces being exerted by nanovibrational stimulation, laser interferometry was performed to measure the amplitudes produced across the Petri dish surfaces. Estima...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research

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Authors: Wu Z, Ma Y PMID: 31707863 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Authors: Kunutsor SK, Mäkikallio TH, Laukkanen JA PMID: 31707862 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
CONCLUSION: There was a good agreement for the size of the NVs in both methods. OCTA can be used as a simple and non-invasive method to visualize retinal neovascularizations. PMID: 31711250 [PubMed - in process]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Publication date: Available online 11 November 2019Source: MethodsAuthor(s): Jennifer I. Brown, Brent D.G. Page, Adam FrankelAbstractProtein arginine N-methyltransferases (PRMTs) are a family of 9 enzymes that catalyze mono- or di-methylation of arginine residues using S-adenosyl-L-methionine (SAM). Arginine methylation is an important post-translational modification that can regulate the activity and structure of target proteins. Altered PRMT activity can lead to a variety of health issues including neurodevelopmental disease, autoimmune disorders, cancer, and cardiovascular disease. Thus, developing a robust mechanistic ...
Source: Methods - Category: Molecular Biology Source Type: research
Publication date: Available online 11 November 2019Source: Polymer TestingAuthor(s): Ji-Hong Liu, Jie-Hua Cai, Xiao-Hong Tang, Yun-Xuan Weng, Ming WangAbstractThe drawback of the application for poly(l-lactide) (PLLA) is the low crystalline rate and crystallinity obtaining via normal processing methods. Modifying crystallization of PLLA has been found to be an efficient way to improve its mechanical and heat resistance properties. In this wok, 4, 4′-diphenylmethane diisocyanate (M) and benzohydrazine (P) were employed into PLLA melt to in-situ form nucleating agents. The in-situ melting reaction was confirmed by a nu...
Source: Polymer Testing - Category: Chemistry Source Type: research
Publication date: Available online 11 November 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Lakshmanan Gurusamy, Sambandam Anandan, Na Liu, Jerry J. WuAbstractNovel bismuth oxide (Bi2O3) nanoparticles dispersed on porous reduced graphene oxide nanosheets is prepared using the facile hydrothermal reaction followed by a calcination process in the air atmosphere. At electrochemical study, the electrode materials of Bi2O3/porous-RGO display the capacitance retention to be 81.1% at a current density of 0.5 Ag-1 and α-MnO2-NRs exhibit about 80.7% at a scan rate of 10 mVs−1 for 3000 cycles in 6 M K...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 11 November 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Koichi Jeremiah Aoki, Jingyuan Chen, Yuanyuan Liu, Bei JiaAbstractCyclic voltammograms of a ferrocenyl derivative in aqueous solution showed diffusion-controlled peak, of which currents deviated downward from the proportionality of the square-root of potential scan rates, v, and of which potentials were shifted with an increase in v. The dependence of the peak on v can be attributed conventionally to sluggish charge transfer rates and the solution resistance. This redox species has been proved to exhibit extremely fa...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 11 November 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Tingting Tang, Zeze Hao, Hongjing Yang, Fei Nie, Wenyan ZhangAbstractA novel copper (Ⅱ) metal-organic framework ([Cu(L)(H2O)2]nCu-MOF) has been successfully synthesized by facile one step hydrothermal method. Modified the glassy carbon electrode (GCE) with this kind of Cu-MOF, a strong cathode electrochemiluminescence (ECL) signal was produced under the potential scan from 0.2 to −1.6 V in the potassium persulfate solution, which was about 8 times higher than that on the bare GCE electrode. The possible enh...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 11 November 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Bruna M. Hryniewicz, Renata V. Lima, Luís F. Marchesi, Marcio VidottiAbstractPolypyrrole nanotubes (PPyNTs) are interesting materials that can be used as supercapacitors due to the high conductivity in the doped state and large surface area, but the limited cycling stability is a common issue that restrict further applications. The loss of capacitance during galvanostatic charge/discharge (GCD) cycles are commonly observed and the reasons for this lack of stability remain unclear. Herein, we demonstrate the ch...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Authors: Baqir H, Nayani K, Mian A, Mian AI Abstract Writing has always been a part of medicine, but it was largely used as a means to disseminate objective data. With changing times, qualitative writing in the form of narrative medicine (NM) is fast coming to the forefront. Data in the field from high-income countries have shown an enhancement in empathy and professionalism alike, for both patients and health care practitioners. Studies also elucidate the benefits of incorporating NM into medical curricula. However, there is scant literature from low-income to middle-income countries concerning NM. In this brief r...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
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