Diabetes Makes Lung Transplant Riskier (CME/CE)
SAN FRANCISCO (MedPage Today) -- Patients with diabetes have poorer outcomes following a lung transplant, researchers reported here.
Conclusion: IT following lung and liver transplantation, with injection of islets into a transplanted organ, is feasible. It improves C-peptide secretion, decreases insulin needs, and lowers HbA1c.Horm Res Paediatr
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
While journalistic treatment of serious rejuvenation research has improved greatly over the past decade, the mainstream media remains decidedly childish at times. Much of the profession of journalism works hard at producing the appearance of educated folk paid to play the fool, writing for an imagined audience of inattentive, ignorant peers, while ensuring that their education slips through the mask just enough to be seen. It degrades the author and insults the world at large. Everyone in this picture is better than they are portrayed, capable of introspection and self-determination. I noted the article here because it vee...
Prolonged-release formulation of tacrolimus (TAC) provides more convenient once-daily dosing and may improve patient adherence. We investigated the effects of conversion from twice-daily (TDT) to once-daily (ODT) TAC on renal function and diabetic parameters in a large cohort of stable lung transplant (LTx) recipients.
New onset diabetes after transplant (NODAT) is an important cause of morbidity and mortality. Single nucleotide polymorphisms (SNPs) associated with early onset diabetes have also been associated with NODAT in kidney transplant recipients. We selected 4 genes based on a meta-analysis in renal transplantation and hypothesized that SNPs within these genes would also convey risk for diabetes following lung transplantation.
Patients with type 2 diabetes mellitus (DM) and systolic heart failure (HF) often show improved glycemic control and reduced diabetes medication requirements after left ventricular assist device (LVAD) implantation. However, LVAD recipients also show increased body mass index (BMI) over time. We sought to determine whether post-LVAD improvements in hemoglobin A1c (HbA1c) are affected by changes in BMI.
Older kidney donors (OKDs) defined as>50 yrs old in dual heart-kidney transplant (HKTx) may have less renal reserve especially when compounded by donor cardiac arrest. Some OKDs may have additional risk factors for renal disease (ie hypertension or diabetes). Whether recipients with OKDs are at greater risk for kidney failure or delayed graft function (DGF) following dual HKTx has not been established. Therefore, we assessed renal function of patients (pts) with OKDs after dual HKTx.
Hemoglobin A1c, a common metric of glycemic control in diabetics, has been associated with various outcomes in the ambulatory heart failure population. Currently, only end organ damage secondary to diabetes is a contraindication to heart transplant (HT) and no optimal A1c prior to HT has been identified.
Lung transplantation is a life-prolonging treatment for end-stage pulmonary diseases. The prevalence of metabolic derangements and cardiovascular (CV) risk factors has not been well-characterized in this population, although CV disease is known to be a significant cause of mortality after lung transplantation. The purpose of this retrospective study was to determine the prevalence of metabolic derangements, including post-transplant diabetes mellitus (PTDM) and dyslipidemia in a cohort of lung transplant recipients at our centre.
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...