IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2R{alpha} therapies [Immunology and Inflammation]
Interleukin-2 (IL-2) and IL-15 play pivotal roles in T cell activation, apoptosis, and survival, and are implicated in leukemias and autoimmune diseases. Their heterotrimeric receptors share their β- and γc-chains, but have distinct α-chains. Anti–IL-2Rα (daclizumab) therapy targeting cell surface-expressed receptor subunits to inhibit T cell proliferation has only brought...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Julianna Volko, Adam Kenesei, Meili Zhang, Peter Varnai, Gabor Mocsar, Michael N. Petrus, Karoly Jambrovics, Zoltan Balaȷthy, Gabriele Muller, Andrea Bodnar, Katalin Toth, Thomas A. Waldmann, Gyorgy Vamosi Tags: Biological Sciences Source Type: research