Effects of SGLT2 Inhibition Treatment on Different Levels of Albuminuria in Patients With Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Diabetic Nephropathy Intervention:   Drug: SGLT2 Inhibition Sponsor:   Zhongshan Hospital Xiamen University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

Related Links:

Conclusions/interpretationShort-term structured strength and balance training did not influence HRQoL but produced sustained improvements in functional status and balance confidence at 6  months. More intensive interventions may be needed to influence HRQoL in these individuals. However, this intervention may be a useful treatment option for individuals with DPN to reduce the risk of falls and injuries.Trial registrationClinicalTrials.gov NCT02115932FundingThis work was supported by the National Medical Research Council, Singapore.
Source: Diabetologia - Category: Endocrinology Source Type: research
AbstractAims/hypothesisDiet is one of the main lifestyle-related factors that can modulate the inflammatory process. Surprisingly the dietary inflammatory index (DII) has been little investigated in relation to type 2 diabetes, and the role of BMI in this relationship is not well established. We studied this association and the role of BMI in the inflammatory process in a large population-based observational study.MethodsA total of 70,991 women from the E3N (Etude Epid émiologique auprès de femmes de la Mutuelle Générale de l’Education Nationale) cohort study were followed for 20 year...
Source: Diabetologia - Category: Endocrinology Source Type: research
Conclusions/interpretationWe observed inverse associations between height and risk of type 2 diabetes, which was largely related to leg length among men. The inverse associations may be partly driven by lower liver fat content and a more favourable cardiometabolic profile.
Source: Diabetologia - Category: Endocrinology Source Type: research
Authors: Sadeghimahalli F, Zardooz H, Golchoobian R Abstract OBJECTIVE: Early life stress influences the development of metabolic disorders, including functional changes in the developing of pancreas mediated hypothalamic-pituitary-adrenal (HPA) axis. In the present study, the role of an early postnatal stress on corticosterone, glucose, and insulin levels was investigated during young adulthood. METHODS: Two groups of pups were studied, including control group (pups not receiving foot shock by communication box), and early stress group (pups receiving foot shock by communication box 2 times/day for 5 consecuti...
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
Authors: Addai D, Zarkos J, Tolekova A Abstract The bones form the framework of our body. We know that bones protect our vital organs, regulate calcium and phosphorous homeostasis, and function as a site of erythropoiesis. More recently, however, the identification of bone hormones has allowed us to envision bones as endocrine organs too. Within the last few years, the bone hormones osteocalcin and lipocalin 2 have been implicated with glucose and energy metabolism. We systematically reviewed articles surrounding this subject and found a clear relationship between the osteocalcin levels and glucose tolerance and in...
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
TYPE 2 diabetes is a common condition which affects a person ’s blood sugar level control, and left untreated, serious health complications can occur. One way to control blood sugar levels could be to eat a vegetable native to the Mediterranean.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion: The epidemiological issues of MetS in Beijing adolescents should be known across socioeconomic classes. Early intervention strategies, such as dietary pattern interventions and physical excise, should be designed for that population to reduce the disease burdens of cardiovascular disease (CVD), Type 2 diabetes (T2D), and steatohepatitis in adulthood.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusion: The survival rate of dental implant placement by conventional and flapless techniques is similar. As few studies on flapless technique are available, therefore researchers in future should explore its advantages and disadvantages.
Source: Indian Journal of Dental Research - Category: Dentistry Authors: Source Type: research
ConclusionsThe safety and efficacy of new hypoglycemic agents are potentially inflated because the participants in the placebo groups unexpectedly exhibited inferior glycemic control throughout the trial compared with the outcomes in the treatment groups. This imbalance may distort data interpretation and mask potential risks of the drugs. Re-analysis with adjustment for HbA1c concentrations would determine whether the results of these CVOTs were biased by the difference in glycemic control between the treatment and placebo groups and reveal potential effects of the test drugs independent of glycemic control.
Source: Journal of Pharmaceutical Policy and Practice - Category: Pharmaceuticals Source Type: research
AbstractIntroductionMedicinal plants have long been recognized for their roles in the treatment and management of diabetes and its complications. The antioxidative and antidiabetic properties ofClerodendrum volubile flowers were investigated in vitro and ex vivo.MethodsThe flowers were sequentially extracted with solvents of increasing polarity (n-hexane, ethyl acetate, ethanol and water). The concentrated extracts were subjected to in vitro antioxidant assays using the 2,2 ′-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Ferric reducing antioxidant power (FRAP) protocols. Their inhibitory activities were investigat...
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
More News: Diabetes | Diabetes Type 2 | Endocrinology | Research | SGLT2 Inhibitors