2534 Opioid Use and Misuse among Gynecologic Oncology Patients

Publication date: November–December 2019Source: Journal of Minimally Invasive Gynecology, Volume 26, Issue 7, SupplementAuthor(s): SR Pena, J Brown, M Wally, R Seymour, JR Hsu, RW NaumannStudy ObjectiveTo determine opioid and benzodiazepine prescribing practices in the gynecologic oncology population and determine if this patient population is at risk for narcotic abuse.DesignThis was an IRB-approved, retrospective study of opioid and benzodiazepine prescriptions for cervical, ovarian (including fallopian tube and primary peritoneal), and uterine cancer patients within a single healthcare system from January 2016 to August 2018. Demographics and prescription details were extracted from the electronic medical record.SettingA tertiary care academic nonprofit healthcare system.Patients or ParticipantsPatients with ovarian, uterine, or cervical cancer that received an opioid or benzodiazepine prescription.InterventionsN/AMeasurements and Main Results6407 prescriptions for opioids/benzodiazepines were dispensed to 3586 patients over a total of 5931 prescribing encounters for cervical (n=1965, 33%), ovarian (n=1801, 30%), or uterine cancers (n=2165, 37%). The setting for prescription distribution was 50.9% outpatient, 25.6% inpatient, and 21% emergency center. Cervical cancer patients were more likely to have received a prescription in an emergency center (p
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research

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Enhanced recovery after surgery is an interdisciplinary, multimodal approach to improve postoperative outcomes by applying multiple evidenced-based interventions. It has been adapted at multiple institutions for patients undergoing spine surgery to combat the rising rate of opioid consumption. Various preoperative, intraoperative, and postoperative pharmacologic and nonpharmacologic interventions have been introduced to augment patient care with the goal to decrease hospital length of stay and improve postoperative outcomes. Future studies will focus on health care-related quality of life outcomes to evaluate the effective...
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
Forensic pathologists are requested to select matrices alternative to blood in cases of toxicological interest in which blood is not available for different reasons. We evaluated morphine concentrations in blood, bile, and liver samples in 52 cases of heroin overdoses, relating them to each other, to understand the information that could be derived from their analysis. Gas chromatography/mass spectrometry analysis was performed for all the samples positive on screening for opiates. Shapiro-Wilk test, nonparametric Mann-Whitney test, linear regression analysis, and Bland-Altman test were used for analysis. Linear regression...
Source: The American Journal of Forensic Medicine and Pathology - Category: Forensic Medicine Tags: Original Articles Source Type: research
Barotrauma-associated perforation of the colon is not common and usually occurs due to the passage of compressed air through the anus. Most of the cases are accidental and done for fun often at the victim's workplace. Therefore, it is necessary that the workers should be made aware of the dangers of the equipment they regularly use at their workplace. Here, we describe one such case where a rice mill worker died when compressed air through an air pump pipe entered his rectum. His chief complaint was abdominal pain and breathing difficulty. Computed tomography scan of the abdomen and thorax showed pneumoperitoneum, pneumome...
Source: The American Journal of Forensic Medicine and Pathology - Category: Forensic Medicine Tags: Original Articles Source Type: research
Publication date: Available online 14 November 2019Source: Life SciencesAuthor(s): Wanli Ji, Kun Liang, Rui An, Xinhong WangAbstractAimsCurrently, chronic gastritis is a high incidence of digestive diseases, along with loss of appetite, abdominal pain and diarrhea. Baicalin belongs to the major bioactive flavonoids compounds from Scutellariae Radix, it exhibited anti-inflammatory and anti-bacteria activities. Nonetheless, the protective effects of baicalin on ethanol-induced gastritis have not been completely clarified. Our study was designed to evaluate the protective activity of baicalin on ethanol-induced chronic gastri...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 15 November 2019Source: Carbohydrate PolymersAuthor(s): Urarika Luesakul, Songchan Puthong, Kanokwan Sansanaphongpricha, Nongnuj MuangsinAbstractA new positively charged nanoemulsion using quaternized chitosan (QCS) as a protective layer was developed to improve the stability and bioactivity of lipophilic active components. The anti-inflammatory Plai extract was chosen as both an active ingredient and an oil phase of the system. Compared with chitosan-coated nanoemulsion (NE2-CS) and uncoated nanoemulsion (NE1), the QCS coating could improve the stability of the Plai extract during 28 day...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 14 November 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Lina Zhu, Beibei Yang, Kun Qian, Liang Qiao, Yun Liu, Baohong LiuAbstractThe epithelial cell adhesion molecule (EpCAM) is a known biomarker of circulating tumor cells that plays an important role in tumor metastasis. The detection of EpCAM is vital for personalized diagnosis and therapy but is challenging because of its extremely low concentration in peripheral blood. In our work, an electrochemical aptasensor has been developed to quantitatively detect EpCAM at low concentrations. A gold electrode modified with an a...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01524H, PaperDongliang Song, Tianming Chen, Shuang Wang, Shilin Chen, Heping Li, Fan Yu, Jingyuan Zhang, Zhe Zhang As a highly invasive and the most prevalent malignancy, lung cancer remains the leading cause of cancer-associated mortality worldwide, especially in China. Microwave ablation (MWA) is a type of effective,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Contributors : Ruben Carrasco ; Meng JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensColorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-activator of the Wnt/ β-catenin pathway, which plays critical roles in CRC pathogenesis. Here we have identified a β-catenin-independent function of BCL9 in a poor-prognosis subtype of CRC tumors characterized by expression of stromal and ne...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Feixue Xu ; Xiaoqiang SiSeries Type : Expression profiling by arrayOrganism : Homo sapiensCADM1, an immunoglobulin superfamily member, frequently inactivated but function as a tumor suppressor in many solid tumors. However, how CADM1 expression in ovarian cancer cells and the mechanisms of its tumor suppressor function is not fully understood.We created ovarian cancer ES-2 cell lines in which CADM1 was stably up-regulated. Genes differentially expressed in CADM1-overexpressing ES-2 cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Ewelina Szyma ńska ; Paulina Nowak ; Krzysztof Kolmus ; Magdalena Cybulska ; Krzysztof Goryca ; Edyta Derezińska-Wołek ; Anna Szumera-Ciećkiewicz ; Marta Brewińska-Olchowik ; Aleksandra Grochowska ; Katarzyna Piwocka ; Monika Prochorec-Sobieszek ; Michał Mikula ; Marta MiączyńskaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSomatic copy number alterations play a critical role in oncogenesis. Loss of chromosomal regions containing tumor suppressors can lead to collateral deletion of passenger genes. This can be exploited therapeutically if synthetic lethal part...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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