Chemoreceptors as a key to understanding carcinogenesis process

Publication date: Available online 14 October 2019Source: Seminars in Cancer BiologyAuthor(s): Leszek Satora, Jennifer Mytych, Anna Bilska-Kos, Katarzyna KoziołAbstractThe tissue organization field theory (TOFT) presented completely new, different from the previous one, perspective of research on neoplasm processes. It implicates that secretory neuroepithelial-like cells (NECs), putative chemoreceptors, are probably responsible for the control of squamous epithelial cells proliferation in digestive tract during hypoxia in gut breathing fish (GBF). On the other hand, chemoreceptors dysfunction can lead to uncontrolled proliferation and risk of cancer development in mammals including humans. The studies on NECs like cells (signal capturing and transduction) may be crucial for understanding the processes of controlling the proliferation of squamous epithelial cells in the digestive tract of GBF fish during hypoxia states. This knowledge can contribute to the explanation of cancer processes.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research