Palliative resection or radiation of primary tumor prolonged survival for metastatic esophageal cancer

This study aimed to evaluate the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer using the Surveillance, Epidemiology, and End Results database. Additionally, we constructed prognostic nomograms for both preoperative and postoperative risk factors. We found that palliative resection or radiation could improve the survival of such patients, across both squamous cell carcinoma and adenocarcinoma. AbstractPurposeWe aimed to explore the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer (EC) patients.MethodsSurveillance, Epidemiology, and End Results database was used for identifying metastatic EC patients. The patients were divided into resection and nonresection groups. And patients without resection were divided into radiation and nonradiation groups. Propensity score matching (PSM) analyses were adopted to reduce the baseline differences between the groups. Cancer specific survivals (CSSs) and overall survivals (OSs) were compared by Kaplan ‐Meier (K‐M) curves. Multivariable analyses by COX proportion hazards model were performed to identify risk factors for CSS and OS. Predictive nomograms were conducted according to both postoperative factors and preoperative factors.ResultsA total of 7982 metastatic EC patients were selected for our analyses. After PSM, 978 patients were included in the survival analyses comparing palliative resection and nonresection. The CSS and OS for patients und...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Conclusion: SEMS effectively reduced dysphagia in inoperable esophageal cancer. Better survival rates were observed in females than males.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
There are two main types of oesophageal cancer, squamous cell carcinoma (SCC) and adenocarcinoma (ACA). SCC usually affects the middle third of the oesophagus and is associated with smoking, alcohol and low socio-economic status. ACA affects the lower third of the oesophagus and is associated with gastro-oesophageal reflux disease. The UK has the highest incidence of ACA in the world and it is rising. Treatment may be palliative or curative. Curative treatment for advanced disease consists of neo-adjuvant chemotherapy or chemoradiotherapy followed by surgery.
Source: Surgery (Medicine Publishing) - Category: Surgery Authors: Tags: Oesophagus and stomach Source Type: research
ConclusionsColonic metastasis from esophageal SCC is rare, and associated with poor prognosis. There are no definite features in terms of location, histological differentiation etc. that contribute to colonic metastasis from primary esophageal SCC. The goal of treatment is palliative and data from our and other case reports support the use of chemotherapy and radiation for symptom improvement and disease control.
Source: Experimental Hematology and Oncology - Category: Cancer & Oncology Source Type: research
Abstract Esophageal cancer has a poor prognosis and high mortality rate, with an estimated 16,910 new cases and 15,910 deaths projected in 2016 in the United States. Squamous cell carcinoma and adenocarcinoma account for more than 95% of esophageal cancers. Squamous cell carcinoma is more common in nonindustrialized countries, and important risk factors include smoking, alcohol use, and achalasia. Adenocarcinoma is the predominant esophageal cancer in developed nations, and important risk factors include chronic gastroesophageal reflux disease, obesity, and smoking. Dysphagia alone or with unintentional weight los...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Publication date: August 2016 Source:Best Practice & Research Clinical Gastroenterology, Volume 30, Issue 4 Author(s): M.C.C.M. Hulshof, H.W.M. van Laarhoven Oesophageal cancer remains a malignancy with a poor prognosis. However, in the recent 10–15 years relevant progress has been made by the introduction of chemoradiotherapy (CRT) for tumours of the oesophagus or gastro-oesophageal junction. The addition of neo-adjuvant CRT to surgery has significantly improved survival and locoregional control, for both adenocarcinoma and squamous cell carcinoma. For irresectable or medically inoperable patients, definitive C...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 25 June 2016 Source:Best Practice & Research Clinical Gastroenterology Author(s): M.C.C.M. Hulshof, H.W.M. van Laarhoven Oesophageal cancer remains a malignancy with a poor prognosis. However, in the recent 10-15 years relevant progress has been made by the introduction of chemoradiotherapy (CRT) for tumours of the oesophagus or gastro-oesophageal junction. The addition of neo-adjuvant CRT to surgery has significantly improved survival and locoregional control, for both adenocarcinoma and squamous cell carcinoma. For irresectable or medically inoperable patients, definitive CRT ha...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Oesophageal cancer remains a malignancy with a poor prognosis. However, in the recent 10 –15 years relevant progress has been made by the introduction of chemoradiotherapy (CRT) for tumours of the oesophagus or gastro-oesophageal junction. The addition of neo-adjuvant CRT to surgery has significantly improved survival and locoregional control, for both adenocarcinoma and squamous cell carcinoma. For irresectable or medically inoperable patients, definitive CRT has changed the treatment intent from palliative to curative.
Source: Best Practice and Research. Clinical Gastroenterology - Category: Gastroenterology Authors: Tags: 4 Source Type: research
Oesophageal cancer remains a malignancy with a poor prognosis. However, in the recent 10-15 years relevant progress has been made by the introduction of chemoradiotherapy (CRT) for tumours of the oesophagus or gastro-oesophageal junction. The addition of neo-adjuvant CRT to surgery has significantly improved survival and locoregional control, for both adenocarcinoma and squamous cell carcinoma. For irresectable or medically inoperable patients, definitive CRT has changed the treatment intent from palliative to curative.
Source: Best Practice and Research. Clinical Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Conclusions MTV predicted poor OS in patients with advanced AC. No PET parameters were associated to OS in ESCC patients.
Source: European Journal of Radiology - Category: Radiology Source Type: research
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