Intergenerational Effects of Sevoflurane in Young Adult Rats

Conclusions Adult sevoflurane exposure affects brain development in male offspring by epigenetically reprogramming both parental germ cells, while it induces neuroendocrine and behavioral abnormalities only in exposed males. Sex steroids may be required for mediation of the adverse effects of adult sevoflurane in exposed males.
Source: Anesthesiology - Category: Anesthesiology Source Type: research