Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation.

Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation.
Chem Commun (Camb). 2019 Oct 14;:
Authors: Zhao J, Yang F, Yu Z, Tang X, Wu Y, Ma C, Meng Q
Abstract
A visible light-mediated α-functionalization of 1,3-dicarbonyl compounds with switchable selectivity induced by disulfide is disclosed. Upon irradiation with visible light, the metal- and base-free α-hydroxylation or α-hydroxymethylation reaction proceeded smoothly through a disulfide-catalyzed oxidation under mild conditions. The combination of a continuous-flow strategy could further improve the reaction efficiencies.
PMID: 31608906 [PubMed - as supplied by publisher]

Source: Chemical Communications - October 13, 2019 Category: Chemistry Authors: Zhao J, Yang F, Yu Z, Tang X, Wu Y, Ma C, Meng Q Tags: Chem Commun (Camb) Source Type: research