A population-based family clustering study of tic-related obsessive-compulsive disorder

Molecular Psychiatry, Published online: 15 October 2019; doi:10.1038/s41380-019-0532-zA population-based family clustering study of tic-related obsessive-compulsive disorder
Source: Molecular Psychiatry - Category: Psychiatry Authors: Source Type: research

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Authors: Guzick AG, Hunt PJ, Bijanki KR, Schneider SC, Sheth SA, Goodman WK, Storch EA Abstract Introduction: Deep brain stimulation (DBS) has emerged as an effective treatment for patients with severe treatment-refractory obsessive-compulsive disorder (OCD). Over the past two decades, several clinical trials with multiple years of follow-up have shown that DBS offers long-term symptom relief for individuals with severe OCD, though a portion of patients do not achieve an adequate response.Areas covered: This review sought to summarize the literature on the efficacy and long-term effectiveness of DBS for OCD, and to id...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Publication date: Available online 14 November 2019Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Randy O. Frost
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
Obsessive compulsive disorder (OCD) is a heterogeneous psychiatric disorder affecting 1%–3% of the population worldwide. About half of OCD afflicted individuals do not respond to currently available pharmacotherapy, which is mainly based on serotonin reuptake inhibition. Therefore, there is a critical need to search novel and improved therapeutic targets to treat this devastating disorder. In recent years, accumulating evidence has supported the glutamatergic hypothesis of OCD, and particularly pointing a potential role for the neuronal glutamate transporter EAAT3. This mini-review summarizes recent findings regardin...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 November 2019Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Juliana Negreiros, John R. Best, Diana Franco Yamin, Laura Belschner, Sarah Lin, S. Evelyn Stewart
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Christiana Bratiotis, Sheila R. Woody
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
Authors: Moritz S, Bernardini J, Lion D Abstract Obsessive-compulsive disorder (OCD) and major depression disorder (MDD) are underdiagnosed and undertreated mental disorders. Prior studies have verified the efficacy of the self-help manual My Metacognitive Training (myMCT) for patients with primary OCD. As depression and OCD share a number of (meta)cognitive biases and dysfunctional coping strategies, we examined the efficacy of myMCT in a mixed patient sample with OCD and/or depression. A total of 80 Italian-speaking individuals with symptoms of OCD and/or depression were randomized to either myMCT or to a waitlis...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Authors: Varshney P, Ganjekar S PMID: 31706227 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Authors: Pontone GM PMID: 31706637 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Conclusion: KY shows promise as an add-on option for OCD patients unresponsive to first line therapies. Future studies will establish KY’s relative efficacy compared to Exposure and Response Prevention and/or medications, and the most effective treatment schedule.Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT01833442.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, patients who failed pharmacotherapy underwent individually tailored provocations just prior to each stimulation session, in the attempt to activate the relevant circuitry and making it labile to change. The procedure that was developed reliably evoked moderate intensity symptoms, making it effective on the one hand and mild enough to allow the patient to continue with the dTMS session on the other. This methodology article describes in a detailed step wise fashion how to evaluate the patient’s specific symptoms and design the individualized provocations. Additionally, the article explains how to instru...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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