Resilience to acute kidney injury in offspring of maternal protein restriction.

Resilience to acute kidney injury in offspring of maternal protein restriction. Am J Physiol Renal Physiol. 2019 Oct 14;: Authors: García-Ortuño LE, Barrera-Chimal J, Pérez-Villalva R, Ortega Trejo JA, Luna-Bolaños E, Lima-Posada IQ, Sanchez-Navarro A, Reyes-Castro LA, Gamba G, Zambrano E, Bobadilla NA Abstract Protein restriction (PR) during pregnancy induces morphofunctional alterations related to deficient nephrogenesis. We studied the renal functional and morphological significance of PR during pregnancy and/or lactation in adult male rat offspring and the repercussions on acute kidney injury severity. Female rats were randomly assigned to the following groups: control diet during pregnancy and lactation (C); control diet during pregnancy and PR diet during lactation (CR); PR during pregnancy and control diet during lactation (RC); and PR during pregnancy and lactation (RR). Three months after birth, at least twelve male offspring of each group randomly underwent either bilateral renal ischemia for 45 min (IR) or sham surgery. Thus, eight groups were studied 24-h after reperfusion: CC, CC+IR, CR, CR+IR, RC, RC+IR, RR and RR+IR. In basal conditions, the CR, RC, and RR groups exhibited a significant reduction in the nephron number that was associated with a reduction in renal blood flow (RBF). Glomerular hyperfiltration was present as a compensatory mechanism to maintain normal renal function. The mRNA levels of several vasoact...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research